Association between high-mobility group box 1 levels and febrile seizures in children: a systematic review and meta-analysis

The relationship between High-mobility group box 1 (HMGB1) and febrile seizures (FS) in children remains unclear. This study aimed to apply meta-analysis to reveal the correlation between HMGB1 levels and FS in children. Databases including PubMed, EMBASE, Web of science, Cochrane library, CNKI, Sin...

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Published in:Scientific reports 2023-03, Vol.13 (1), p.3619-3619, Article 3619
Main Authors: Li, Shangbin, Zhao, Qian, Sun, Jingfei, Yan, Weichen, Wang, Jie, Gao, Xiong, Li, Xueying, Ren, Changjun, Hao, Ling
Format: Article
Language:English
Subjects:
631/378
692/308
Child
Children
Clinical trials
Convulsions & seizures
Databases, Factual
Epilepsy
Fever
Gene Library
Genetics
Heterogeneity
HMGB1 Protein
Humanities and Social Sciences
Humans
Meta-analysis
Mobility
multidisciplinary
Science
Science (multidisciplinary)
Seizures
Seizures, Febrile
Sensitivity analysis
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Summary:The relationship between High-mobility group box 1 (HMGB1) and febrile seizures (FS) in children remains unclear. This study aimed to apply meta-analysis to reveal the correlation between HMGB1 levels and FS in children. Databases including PubMed, EMBASE, Web of science, Cochrane library, CNKI, SinoMed and WanFangData were searched for relevant studies. Pooled standard mean deviation and 95% confidence interval were calculated as effect size since the random-effects model was used when I 2  > 50%. Meanwhile, between-study heterogeneity was determined by performing subgroup and sensitivity analyses. A total of 9 studies were finally included. Meta-analysis showed that the children with FS had significantly higher HMGB1 levels compared with healthy children and children with fever but no seizures (P
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-30713-w