Analysis of potential protective effects of caffeic acid phenethyl ester against gentamicin ototoxicity: An experimental study

In this study, it is aimed to investigate the potential protective effect of caffeic acid phenethyl ester (CAPE) on ototoxicity caused by gentamicin in a rat model. Thirty Wistar albino rats were divided into 3 groups. Group I was selected as the control group. Gentamicin was administered intraperit...

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Bibliographic Details
Published in:Iranian journal of basic medical sciences 2022-01, Vol.25 (1), p.121-125
Main Authors: Aydemir, Fuat, Ulku, Cagatay Han, Elmas, Cigdem, Seymen, Cemile Merve
Format: Article
Language:English
Subjects:
Acids
aminoglycoside
anti-oxidant
Antibiotics
caffeic acid phenethyl ester
Drug dosages
Ears & hearing
Electrodes
gentamicin
Laboratory animals
Original
Otolaryngology
ototoxicity
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Summary:In this study, it is aimed to investigate the potential protective effect of caffeic acid phenethyl ester (CAPE) on ototoxicity caused by gentamicin in a rat model. Thirty Wistar albino rats were divided into 3 groups. Group I was selected as the control group. Gentamicin was administered intraperitoneally in group II, gentamicin and CAPE in group III. Audiological assessment was performed by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) measurements before and after treatment of each group. At the end of the study all rats were decapitated, cochlea was removed and electron microscopic examination was performed. In group II post-treatment DPOAE levels were found to be lower than pretreatment DPOAE levels ( 0.05). Except for Group I, ABR thresholds increased after the procedure and this increase was statistically significant (
ISSN:2008-3866
2008-3874
DOI:10.22038/IJBMS.2022.60794.13467