Post-Contrast Acute Kidney Injury in Patients with Various Stages of Chronic Kidney Disease-Is Fear Justified?

Post-contrast acute kidney injury (PC-AKI) is one of the side effects of iodinated contrast media, including those used in computed tomography. Its incidence seems exaggerated, and thus we decided to try estimate that number and investigate its significance in our clinical practice. We analyzed all...

Full description

Saved in:
Bibliographic Details
Published in:Toxins 2021-06, Vol.13 (6), p.395
Main Authors: Chomicka, Inga, Kwiatkowska, Marlena, Lesniak, Alicja, Malyszko, Jolanta
Format: Article
Language:English
Subjects:
Abdomen
acute kidney injury
Acute Kidney Injury - blood
Acute Kidney Injury - diagnostic imaging
Acute Kidney Injury - epidemiology
Acute Kidney Injury - physiopathology
Aged
Clinical medicine
Computed tomography
Contrast agents
Contrast media
Contrast Media - administration & dosage
Creatinine
Creatinine - blood
Fear
Female
Glomerular Filtration Rate
Hospitalization
Humans
Hydration
iodinated contrast media
Iodine
Kidney diseases
Kidneys
Male
Patients
post-contrast acute kidney injury
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnostic imaging
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - physiopathology
Risk Factors
Side effects
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Post-contrast acute kidney injury (PC-AKI) is one of the side effects of iodinated contrast media, including those used in computed tomography. Its incidence seems exaggerated, and thus we decided to try estimate that number and investigate its significance in our clinical practice. We analyzed all computed tomographies performed in our clinic in 2019, including data about the patient and the procedure. In each case, we recorded the parameters of kidney function (serum creatinine concentration and eGFR) in four time intervals: before the test, immediately after the test, 14-28 days after the test, and over 28 days after the test. Patients who did not have a follow-up after computed tomography were excluded. After reviewing 706 CT scans performed in 2019, we included 284 patients undergoing contrast-enhanced CT and 67 non-enhanced CT in the final analysis. On this basis, we created two comparable groups in terms of age, gender, the severity of chronic kidney disease, and the number of comorbidities. We found that AKI was more common in the non-enhanced CT population (25.4% vs. 17.9%). In terms of our experience, it seems that PC-AKI is not a great risk for patients, even those with chronic kidney disease. Consequently, the fear of using contrast agents is not justified.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins13060395