Clinical Characteristics and Relevance of Oral Candida Biofilm in Tongue Smears

Dimorphic exist as commensal yeast carriages or infiltrate hyphae in the oral cavity. Here, we investigated the clinical relevance of hyphae in non-pseudomembranous oral candidiasis (OC) by smears of tongue biofilms. We conducted a retrospective study of 2829 patients who had had tongue smears regar...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2021-01, Vol.7 (2), p.77
Main Authors: Cho, Eunae, Park, YounJung, Kim, Ki-Yeol, Han, Dawool, Kim, Hyun Sil, Kwon, Jeong-Seung, Ahn, Hyung-Joon
Format: Article
Language:English
Subjects:
atrophic candidiasis
Atrophy
biofilm
Biofilms
Blood
Candida
Candidiasis
Datasets
erythematous candidiasis
Hyphae
Infections
Medical records
Morphology
Nutrient deficiency
oral candidiasis
Oral cavity
Pain
Risk factors
Tongue
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Summary:Dimorphic exist as commensal yeast carriages or infiltrate hyphae in the oral cavity. Here, we investigated the clinical relevance of hyphae in non-pseudomembranous oral candidiasis (OC) by smears of tongue biofilms. We conducted a retrospective study of 2829 patients who had had tongue smears regardless of OC suspicion. Clinical characteristics were evaluated using a novel method of assessing hyphae. Clinical factors (moderate/severe stimulated pain, pain aggravated by stimulation, tongue dorsum appearance and initial topical antifungal use) were highly significant in the high-grade hyphae group but were statistically similar in the low-grade hyphae and non-observed hyphae group, suggesting low-grade hyphae infection as a subclinical OC state. In addition to erythematous candidiasis (EC), a new subtype named "morphologically normal symptomatic candidiasis" (MNSC) with specific pain patterns and normal tongue morphology was identified. MNSC had a significantly higher proportion of moderate and severe stimulated pain cases than EC. Low unstimulated salivary flow rate (
ISSN:2309-608X
2309-608X
DOI:10.3390/jof7020077