Stereotactic body proton therapy for liver tumors: Dosimetric advantages and their radiobiological and clinical implications

Photon Stereotactic Body Radiotherapy (SBRT) for primary and metastatic tumors of the liver is challenging for larger lesions. An in silico comparison of paired SBRT and Stereotactic Body Proton Therapy (SBPT) plans was performed to understand the potential advantages of SBPT as a function of tumor...

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Bibliographic Details
Published in:Physics and imaging in radiation oncology 2018-10, Vol.8, p.17-22
Main Authors: Arscott, W. Tristram, Thompson, Reid F., Yin, Lingshu, Burgdorf, Brendan, Kirk, Maura, Ben-Josef, Edgar
Format: Article
Language:English
Subjects:
Liver SBRT
NTCP
Original
Proton SBRT
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Summary:Photon Stereotactic Body Radiotherapy (SBRT) for primary and metastatic tumors of the liver is challenging for larger lesions. An in silico comparison of paired SBRT and Stereotactic Body Proton Therapy (SBPT) plans was performed to understand the potential advantages of SBPT as a function of tumor size and location. Theoretical tumor volumes with maximum diameter of 1–10 cm were contoured in the dome, right inferior, left medial, and central locations. SBRT and SBPT plans were generated to deliver 50 Gy in 5 fractions, max dose 
ISSN:2405-6316
2405-6316
DOI:10.1016/j.phro.2018.11.004