Pulmonary oxidative stress in diabetic rats exposed to hyperoxia

Abstract Purpose: To evaluate the pulmonary oxidative stress in diabetic rats exposed to hyperoxia for 90 minutes. Methods: Forty male Wistar rats were divided into four groups, each one containing 10 animals, according to the oxygen concentration to which they were exposed: 21%, 50%, 75% and 100% (...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2017-07, Vol.32 (7), p.503-514
Main Authors: Paiva, Letícia Alves, Silva, Iandara Schettert, Souza, Albert Schiaveto de, Cassino, Pedro Carvalho
Format: Article
Language:English
Subjects:
Diabetes Mellitus, Experimental
Lung
Oxidative Stress
Oxygen
Rats
Streptozocin
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Summary:Abstract Purpose: To evaluate the pulmonary oxidative stress in diabetic rats exposed to hyperoxia for 90 minutes. Methods: Forty male Wistar rats were divided into four groups, each one containing 10 animals, according to the oxygen concentration to which they were exposed: 21%, 50%, 75% and 100% (hyperoxia). In each group five animals were randomly induced to diabetes by means of at a dose of 55 mg/kg of streptozotocin (STZ). Results: Seventy two hours after diabetes induction, a significant difference was seen in blood glucose in the experimental groups in comparison with the control. In the experimental groups a significant difference was observed in the concentration of malondialdehyde (MDA) in lung tissue and blood plasma (p
ISSN:0102-8650
0102-8650
DOI:10.1590/s0102-865020170070000001