Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts

[...]out of the three O-Swiss that showed metastases, only one had been preceded by a primary tumour (MRD period of 36.5 weeks). [...]MRD-PDX developed by orthotopic implantation in NSG mice followed by surgical removal of the primary tumour accurately simulate the clinical behaviour of STS. ACKNOWL...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and translational medicine 2023-06, Vol.13 (6), p.e1290-n/a
Main Authors: Fischer, Suzanne, Creytens, David, De Geyter, Sofie, De Vlieghere, Elly, Pattyn, Piet, Bekaert, Sarah‐Lee, Durinck, Kaat, Van Roy, Nadine, Hendrix, An, Lapeire, Lore, Sys, Gwen, De Wever, Olivier
Format: Article
Language:English
Subjects:
Animals
Cancer
Conflicts of interest
Disease Models, Animal
Fibroblasts
Genomes
Heterografts
Humans
Letter to the Editor
Metastasis
Neoplasm Recurrence, Local
Neoplasm, Residual
Patients
Precision medicine
Sarcoma
Sarcoma - pathology
Sarcoma - surgery
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - surgery
Tumors
Usability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[...]out of the three O-Swiss that showed metastases, only one had been preceded by a primary tumour (MRD period of 36.5 weeks). [...]MRD-PDX developed by orthotopic implantation in NSG mice followed by surgical removal of the primary tumour accurately simulate the clinical behaviour of STS. ACKNOWLEDGEMENTS The authors would like to thank the nurses working at the operating theatre of the Ghent University Hospital and the residents of the pathology department for assisting in the collection of tumour material.
ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.1290