Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis

• Published in: Anais brasileiros de dermatología 2021-03, Vol.96 (2), p.163-170
• Main Authors: Jiménez, Constanza, Carvajal, Daniela, Hernández, Marcela, Valenzuela, Fernando, Astorga, Jessica, Fernández, Alejandra
• Format: Article
• Language: English
• Subjects: Calgranulin A; Cross-Sectional Studies; Cytokinesis; DERMATOLOGY; Gingival Crevicular Fluid; Humans; Interleukin-17; Interleukin-22; Interleukin-23 Subunit p19; Interleukins; Original; Periodontal diseases; Periodontitis; Pilot Projects; Psoriasis; S100 Proteins
• ISSN: 0365-0596; 1806-4841; 1806-4841
• DOI: 10.1016/j.abd.2020.08.008

Psoriasis and periodontitis are immunologically mediated chronic inflammatory diseases. Epidemiologic evidence has linked both; however, the change of markers in gingival crevicular fluid has been poorly evaluated. To evaluate the levels of IL-17A, IL-22, IL-23, S100A7, S100A8, and S100A9 in gingival crevicular fluid of psoriatic and healthy subjects with and without periodontitis and their relations to psoriasis severity. Cross-sectional study. Sample comprised the following groups: healthy controls without periodontitis or with mild periodontitis (n=21), healthy controls with moderate or severe periodontitis (n=18), individuals with psoriasis without or mild periodontitis (n=11), and individuals with psoriasis and moderate or severe periodontitis (n=32). Levels of IL-17A, IL-22, IL-23, S100A8, and S100A9 were determined by multiplex assay and S100A7 was measured by ELISA. No inter-group differences in the levels of IL-17A, IL-22, IL-23, and S100A7 were found. S100A8 levels were higher in psoriatic patients than controls (p