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In vitro evaluation of Pandanus amaryllifolius ethanol extract for induction of cell death on non-hormone dependent human breast adenocarcinoma MDA-MB-231 cell via apoptosis
Our previous study had shown that P. amaryllifolius was able to selectively inhibit cell proliferation of hormone independent breast cancer cell line MDA-MB-231. To understand the mode of killing and mechanism of action for P. amaryllifolius, the ethanol extract was evaluated for their alteration of...
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| Published in: | BMC complementary and alternative medicine 2012-08, Vol.12 (1), p.134-134, Article 134 |
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| container_title | BMC complementary and alternative medicine |
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| creator | Chong, Hueh Zan Yeap, Swee Keong Rahmat, Asmah Akim, Abdah Md Alitheen, Noorjahan Banu Othman, Fauziah Gwendoline-Ee, Cheng Lian |
| description | Our previous study had shown that P. amaryllifolius was able to selectively inhibit cell proliferation of hormone independent breast cancer cell line MDA-MB-231. To understand the mode of killing and mechanism of action for P. amaryllifolius, the ethanol extract was evaluated for their alteration of cell cycle progression, PS externalization, DNA fragmentation and expression of anti/pro-apoptotic related protein.
Cell cycle progression analysis, Annexin V and Tunel assays suggested that IC50 of P. amaryllifolius ethanol extract induced G0/G1 cell cycle arrest, PS externalization and DNA fragmentation. On the other hand, ELISA for cytochrome c, caspase-3/7, 8 and 9 indicated that apoptosis was contributed by mitochondrial cytochrome c release via induction of caspase 3/7, 9, and p53 was associated with the suppression of XIAP in P. amaryllifolius treated MDA-MB-231 cells.
Our findings suggest that P. amaryllifolius ethanol extract induced apoptosis on hormone independent breast cancer cell line MDA-MB-231. |
| doi_str_mv | 10.1186/1472-6882-12-134 |
| format | article |
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Cell cycle progression analysis, Annexin V and Tunel assays suggested that IC50 of P. amaryllifolius ethanol extract induced G0/G1 cell cycle arrest, PS externalization and DNA fragmentation. On the other hand, ELISA for cytochrome c, caspase-3/7, 8 and 9 indicated that apoptosis was contributed by mitochondrial cytochrome c release via induction of caspase 3/7, 9, and p53 was associated with the suppression of XIAP in P. amaryllifolius treated MDA-MB-231 cells.
Our findings suggest that P. amaryllifolius ethanol extract induced apoptosis on hormone independent breast cancer cell line MDA-MB-231.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/1472-6882-12-134</identifier><identifier>PMID: 22909149</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adenocarcinoma ; Adenocarcinoma - drug therapy ; Adenocarcinoma - physiopathology ; Alcohol ; Alcohol, Denatured ; Analysis ; Annexin V ; Apoptosis ; Apoptosis - drug effects ; Biochemistry ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - physiopathology ; Cancer ; Caspase ; Caspase-3 ; Cell cycle ; Cell Line, Tumor ; Cell proliferation ; Cell Proliferation - drug effects ; Cytochrome c ; Cytotoxicity ; DNA fragmentation ; Drug Evaluation, Preclinical ; Enzyme-linked immunosorbent assay ; Ethanol ; Female ; Flow cytometry ; Health sciences ; Hormones ; Hormones - metabolism ; Humans ; Kinases ; Materia medica, Vegetable ; MDA-MB-231 ; Medical equipment and supplies industry ; Medical research ; Medical test kit industry ; Mitochondria ; Oncology, Experimental ; p53 protein ; Pandanaceae - chemistry ; Pandanus ; Pandanus amaryllifolius ; Physiological aspects ; Phytochemicals ; Plant extracts ; Plant Extracts - pharmacology ; Proteins ; Signal transduction ; Studies ; Tumor cell lines ; Tumor proteins ; XIAP protein</subject><ispartof>BMC complementary and alternative medicine, 2012-08, Vol.12 (1), p.134-134, Article 134</ispartof><rights>COPYRIGHT 2012 BioMed Central Ltd.</rights><rights>2012 Chong et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2012 Chong et al.; licensee BioMed Central Ltd. 2012 Chong et al.; licensee BioMed Central Ltd.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b681t-32fce219757bc18ff833081fb36b0583ce52462cbbc8acb62049e3b0866b74dd3</citedby><cites>FETCH-LOGICAL-b681t-32fce219757bc18ff833081fb36b0583ce52462cbbc8acb62049e3b0866b74dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479033/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479033/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22909149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chong, Hueh Zan</creatorcontrib><creatorcontrib>Yeap, Swee Keong</creatorcontrib><creatorcontrib>Rahmat, Asmah</creatorcontrib><creatorcontrib>Akim, Abdah Md</creatorcontrib><creatorcontrib>Alitheen, Noorjahan Banu</creatorcontrib><creatorcontrib>Othman, Fauziah</creatorcontrib><creatorcontrib>Gwendoline-Ee, Cheng Lian</creatorcontrib><title>In vitro evaluation of Pandanus amaryllifolius ethanol extract for induction of cell death on non-hormone dependent human breast adenocarcinoma MDA-MB-231 cell via apoptosis</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Our previous study had shown that P. amaryllifolius was able to selectively inhibit cell proliferation of hormone independent breast cancer cell line MDA-MB-231. To understand the mode of killing and mechanism of action for P. amaryllifolius, the ethanol extract was evaluated for their alteration of cell cycle progression, PS externalization, DNA fragmentation and expression of anti/pro-apoptotic related protein.
Cell cycle progression analysis, Annexin V and Tunel assays suggested that IC50 of P. amaryllifolius ethanol extract induced G0/G1 cell cycle arrest, PS externalization and DNA fragmentation. On the other hand, ELISA for cytochrome c, caspase-3/7, 8 and 9 indicated that apoptosis was contributed by mitochondrial cytochrome c release via induction of caspase 3/7, 9, and p53 was associated with the suppression of XIAP in P. amaryllifolius treated MDA-MB-231 cells.
Our findings suggest that P. amaryllifolius ethanol extract induced apoptosis on hormone independent breast cancer cell line MDA-MB-231.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - physiopathology</subject><subject>Alcohol</subject><subject>Alcohol, Denatured</subject><subject>Analysis</subject><subject>Annexin V</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biochemistry</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - physiopathology</subject><subject>Cancer</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cell cycle</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cytochrome c</subject><subject>Cytotoxicity</subject><subject>DNA fragmentation</subject><subject>Drug Evaluation, Preclinical</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Ethanol</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Health sciences</subject><subject>Hormones</subject><subject>Hormones - metabolism</subject><subject>Humans</subject><subject>Kinases</subject><subject>Materia medica, Vegetable</subject><subject>MDA-MB-231</subject><subject>Medical equipment and supplies industry</subject><subject>Medical research</subject><subject>Medical test kit industry</subject><subject>Mitochondria</subject><subject>Oncology, Experimental</subject><subject>p53 protein</subject><subject>Pandanaceae - chemistry</subject><subject>Pandanus</subject><subject>Pandanus amaryllifolius</subject><subject>Physiological aspects</subject><subject>Phytochemicals</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Studies</subject><subject>Tumor cell lines</subject><subject>Tumor proteins</subject><subject>XIAP protein</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqFk0tv1DAUhSMEoqWwZ4UsISE2KX7FcTZIbXmN1AoWsLZsx25cJfZgOyP4UfxHnE5bZlARiqUkx989ic69rqrnCB4jxNkbRFtcM85xjcoi9EF1eCc93Hk-qJ6kdAUhajmij6sDjDvYIdodVr9WHmxcjgGYjRxnmV3wIFjwRfpe-jkBOcn4cxydDaMrryYP0ocRmB85Sp2BDRE438_6tlCbcQS9kXkARfDB10OIU_CmiGvje-MzGOZJeqCikSkDWaSgZdTOh0mCi3cn9cVpjQnaWm2cBHId1jkkl55Wj6wck3l2cz-qvn14__XsU33--ePq7OS8VoyjXBNstcGoa5tWacSt5YRAjqwiTMGGE20aTBnWSmkutWIY0s4QBTljqqV9T46q1da3D_JKrKNbQhBBOnEthHgpZMxOj0Z0yrK-5apjvaGNQooZAyXq2850tsFN8Xq79VrPajK9LgFEOe6Z7u94N4jLsBGEth0kpBicbQ2UC_8w2N_RYRJL68XSeoHKIrS4vL75jRi-zyZlMbm0JCy9CXMqDOYN7PD1B_-DItTAElqDCvryL_QqzNGX3iwUpe0C_aEuZUnMeRuW4VlMxUlDKGJNy5agju-hytWbyekyQdYVfa_g1U7BYOSYhxTGeRnFtA_CLahjSCkaexcegmI5SPfF9WK3a3cFtyeH_AZjYhlZ</recordid><startdate>20120822</startdate><enddate>20120822</enddate><creator>Chong, Hueh Zan</creator><creator>Yeap, Swee Keong</creator><creator>Rahmat, Asmah</creator><creator>Akim, Abdah Md</creator><creator>Alitheen, Noorjahan Banu</creator><creator>Othman, Fauziah</creator><creator>Gwendoline-Ee, Cheng Lian</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120822</creationdate><title>In vitro evaluation of Pandanus amaryllifolius ethanol extract for induction of cell death on non-hormone dependent human breast adenocarcinoma MDA-MB-231 cell via apoptosis</title><author>Chong, Hueh Zan ; Yeap, Swee Keong ; Rahmat, Asmah ; Akim, Abdah Md ; Alitheen, Noorjahan Banu ; Othman, Fauziah ; Gwendoline-Ee, Cheng Lian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b681t-32fce219757bc18ff833081fb36b0583ce52462cbbc8acb62049e3b0866b74dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - physiopathology</topic><topic>Alcohol</topic><topic>Alcohol, Denatured</topic><topic>Analysis</topic><topic>Annexin V</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biochemistry</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - physiopathology</topic><topic>Cancer</topic><topic>Caspase</topic><topic>Caspase-3</topic><topic>Cell cycle</topic><topic>Cell Line, Tumor</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cytochrome c</topic><topic>Cytotoxicity</topic><topic>DNA fragmentation</topic><topic>Drug Evaluation, Preclinical</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Ethanol</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Health sciences</topic><topic>Hormones</topic><topic>Hormones - metabolism</topic><topic>Humans</topic><topic>Kinases</topic><topic>Materia medica, Vegetable</topic><topic>MDA-MB-231</topic><topic>Medical equipment and supplies industry</topic><topic>Medical research</topic><topic>Medical test kit industry</topic><topic>Mitochondria</topic><topic>Oncology, Experimental</topic><topic>p53 protein</topic><topic>Pandanaceae - 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To understand the mode of killing and mechanism of action for P. amaryllifolius, the ethanol extract was evaluated for their alteration of cell cycle progression, PS externalization, DNA fragmentation and expression of anti/pro-apoptotic related protein.
Cell cycle progression analysis, Annexin V and Tunel assays suggested that IC50 of P. amaryllifolius ethanol extract induced G0/G1 cell cycle arrest, PS externalization and DNA fragmentation. On the other hand, ELISA for cytochrome c, caspase-3/7, 8 and 9 indicated that apoptosis was contributed by mitochondrial cytochrome c release via induction of caspase 3/7, 9, and p53 was associated with the suppression of XIAP in P. amaryllifolius treated MDA-MB-231 cells.
Our findings suggest that P. amaryllifolius ethanol extract induced apoptosis on hormone independent breast cancer cell line MDA-MB-231.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>22909149</pmid><doi>10.1186/1472-6882-12-134</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1472-6882 |
| ispartof | BMC complementary and alternative medicine, 2012-08, Vol.12 (1), p.134-134, Article 134 |
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| source | PubMed Central |
| subjects | Adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - physiopathology Alcohol Alcohol, Denatured Analysis Annexin V Apoptosis Apoptosis - drug effects Biochemistry Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - physiopathology Cancer Caspase Caspase-3 Cell cycle Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cytochrome c Cytotoxicity DNA fragmentation Drug Evaluation, Preclinical Enzyme-linked immunosorbent assay Ethanol Female Flow cytometry Health sciences Hormones Hormones - metabolism Humans Kinases Materia medica, Vegetable MDA-MB-231 Medical equipment and supplies industry Medical research Medical test kit industry Mitochondria Oncology, Experimental p53 protein Pandanaceae - chemistry Pandanus Pandanus amaryllifolius Physiological aspects Phytochemicals Plant extracts Plant Extracts - pharmacology Proteins Signal transduction Studies Tumor cell lines Tumor proteins XIAP protein |
| title | In vitro evaluation of Pandanus amaryllifolius ethanol extract for induction of cell death on non-hormone dependent human breast adenocarcinoma MDA-MB-231 cell via apoptosis |
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