Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study

ObjectivesAlthough platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with mortality rates to reveal the role of platelets in...

Full description

Saved in:
Bibliographic Details
Published in:BMJ open 2023-04, Vol.13 (4), p.e069027-e069027
Main Authors: Liu, Xing, Yin, Wanhong, Li, Yi, Qin, Yiwei, Zou, Tongjuan
Format: Article
Language:English
Subjects:
adult intensive & critical care
Collaboration
Critical Care
Humans
infectious diseases
intensive & critical care
Intensive Care
Intensive Care Units
Medical prognosis
Missing data
Mortality
Observational studies
Patients
Peptides
Physiology
Platelet Count
Prognosis
Regression analysis
Retrospective Studies
Sepsis
Sepsis - therapy
Survival analysis
Thrombocytopenia
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ObjectivesAlthough platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with mortality rates to reveal the role of platelets in sepsis therapy.DesignA retrospective cohort study.SettingWe screened the Medical Information Mart for Intensive Care (MIMIC-IV), a public database comprising data from critical care subjects at the Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts, USA.ParticipantsA total of 7981 patients, who were admitted to the BIDMC between 2008 and 2019, were analysed based on Sepsis-3 criteria from MIMIC-IV.Primary and secondary outcome measuresPrimary and secondary outcomes included 30-day mortality after admission and length of intensive care unit (ICU) stay and hospitalisation, respectively.ResultsPatients with ≤10% reduction in proportion of platelet counts were associated with significantly lower 30-day mortality (14.1% vs 23.5%, p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-069027