Hematological parameters and early-onset coronary artery disease: a retrospective case–control study based on 3366 participants

Background: Thrombosis and inflammation are crucial elements in the pathogenesis of cardiovascular disease. Hematological parameters elucidate information involving the inflammatory and blood coagulation processes. Objectives: The current study explored the association of hematological parameters wi...

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Published in:Therapeutic advances in chronic disease 2023-01, Vol.14, p.20406223221142670
Main Authors: Wang, Huan, Li, Hui, Wang, Yan, Zhao, Cong, Tian, Qing-Wu, Wang, Qing, He, Guo-Wei, Lun, Li-Min, Xuan, Chao
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Language:English
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Blood
Cardiovascular disease
Chronic illnesses
Coronary vessels
Hematology
Hemoglobin
Original Research
Vein & artery diseases
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Li, Hui
Wang, Yan
Zhao, Cong
Tian, Qing-Wu
Wang, Qing
He, Guo-Wei
Lun, Li-Min
Xuan, Chao
description Background: Thrombosis and inflammation are crucial elements in the pathogenesis of cardiovascular disease. Hematological parameters elucidate information involving the inflammatory and blood coagulation processes. Objectives: The current study explored the association of hematological parameters with EOCAD to identify specific risk factors. Design: A single-center retrospective case–control study was conducted with 1693 coronary artery disease patients and 1693 controls. Methods: Hematological parameters were examined through an automated analyzer. Results: The basophil percentage was significantly reduced in EOCAD (0.43 ± 0.26, p 
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Hematological parameters elucidate information involving the inflammatory and blood coagulation processes. Objectives: The current study explored the association of hematological parameters with EOCAD to identify specific risk factors. Design: A single-center retrospective case–control study was conducted with 1693 coronary artery disease patients and 1693 controls. Methods: Hematological parameters were examined through an automated analyzer. Results: The basophil percentage was significantly reduced in EOCAD (0.43 ± 0.26, p &lt; 0.001) and MI (0.33 ± 0.24, p &lt; 0.001) groups compared with controls (0.54 ± 0.28). The eosinophil percentage was also significantly lower in EOCAD (2.21 ± 1.71, p &lt; 0.001) and MI (1.71 ± 2.44, p &lt; 0.001) groups compared with controls (2.41 ± 1.75). The lymphocyte percentage in patients of EOCAD and MI and controls was 31.65 ± 7.93, 25.48 ± 9.43, and 34.82 ± 7.28, respectively. A significant difference was observed among the groups (p &lt; 0.001). Except for the mean corpuscular hemoglobin (MCH), other red blood cell (RBC) parameters significantly differed between EOCAD patients and controls. The red blood cell distribution width (RDW), hematocrit (HCT), RBC count, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and hemoglobin level were associated with EOCAD prevalence after adjusting for baseline differences. Platelet volume distribution width (PDW) also correlated with EOCAD prevalence (ORadjust = 1.087, 95% CI: 1.044–1.131). Conclusions: Hematological parameters are closely associated with EOCAD. Moreover, leukocyte parameters correlated with the presence and severity of the disease. In addition, erythrocyte parameters were associated with the disease presence but not with the disease severity. Among the platelet parameters, only PDW was related to the disease presence.</description><identifier>ISSN: 2040-6223</identifier><identifier>EISSN: 2040-6231</identifier><identifier>DOI: 10.1177/20406223221142670</identifier><identifier>PMID: 36699111</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Blood ; Cardiovascular disease ; Chronic illnesses ; Coronary vessels ; Hematology ; Hemoglobin ; Original Research ; Vein &amp; artery diseases</subject><ispartof>Therapeutic advances in chronic disease, 2023-01, Vol.14, p.20406223221142670</ispartof><rights>The Author(s), 2023</rights><rights>The Author(s), 2023.</rights><rights>The Author(s), 2023. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s), 2023 2023 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-f228acbfbda08d121cd52e952430360dcaa46080882042dcf874fcf7803065fd3</citedby><cites>FETCH-LOGICAL-c499t-f228acbfbda08d121cd52e952430360dcaa46080882042dcf874fcf7803065fd3</cites><orcidid>0000-0001-8273-0178</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869207/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2920174601?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,21964,25751,27851,27922,27923,37010,44588,44943,45331,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36699111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Zhao, Cong</creatorcontrib><creatorcontrib>Tian, Qing-Wu</creatorcontrib><creatorcontrib>Wang, Qing</creatorcontrib><creatorcontrib>He, Guo-Wei</creatorcontrib><creatorcontrib>Lun, Li-Min</creatorcontrib><creatorcontrib>Xuan, Chao</creatorcontrib><title>Hematological parameters and early-onset coronary artery disease: a retrospective case–control study based on 3366 participants</title><title>Therapeutic advances in chronic disease</title><addtitle>Ther Adv Chronic Dis</addtitle><description>Background: Thrombosis and inflammation are crucial elements in the pathogenesis of cardiovascular disease. Hematological parameters elucidate information involving the inflammatory and blood coagulation processes. Objectives: The current study explored the association of hematological parameters with EOCAD to identify specific risk factors. Design: A single-center retrospective case–control study was conducted with 1693 coronary artery disease patients and 1693 controls. Methods: Hematological parameters were examined through an automated analyzer. Results: The basophil percentage was significantly reduced in EOCAD (0.43 ± 0.26, p &lt; 0.001) and MI (0.33 ± 0.24, p &lt; 0.001) groups compared with controls (0.54 ± 0.28). The eosinophil percentage was also significantly lower in EOCAD (2.21 ± 1.71, p &lt; 0.001) and MI (1.71 ± 2.44, p &lt; 0.001) groups compared with controls (2.41 ± 1.75). The lymphocyte percentage in patients of EOCAD and MI and controls was 31.65 ± 7.93, 25.48 ± 9.43, and 34.82 ± 7.28, respectively. A significant difference was observed among the groups (p &lt; 0.001). Except for the mean corpuscular hemoglobin (MCH), other red blood cell (RBC) parameters significantly differed between EOCAD patients and controls. The red blood cell distribution width (RDW), hematocrit (HCT), RBC count, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and hemoglobin level were associated with EOCAD prevalence after adjusting for baseline differences. Platelet volume distribution width (PDW) also correlated with EOCAD prevalence (ORadjust = 1.087, 95% CI: 1.044–1.131). Conclusions: Hematological parameters are closely associated with EOCAD. Moreover, leukocyte parameters correlated with the presence and severity of the disease. In addition, erythrocyte parameters were associated with the disease presence but not with the disease severity. 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Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Therapeutic advances in chronic disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Huan</au><au>Li, Hui</au><au>Wang, Yan</au><au>Zhao, Cong</au><au>Tian, Qing-Wu</au><au>Wang, Qing</au><au>He, Guo-Wei</au><au>Lun, Li-Min</au><au>Xuan, Chao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematological parameters and early-onset coronary artery disease: a retrospective case–control study based on 3366 participants</atitle><jtitle>Therapeutic advances in chronic disease</jtitle><addtitle>Ther Adv Chronic Dis</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>14</volume><spage>20406223221142670</spage><pages>20406223221142670-</pages><issn>2040-6223</issn><eissn>2040-6231</eissn><abstract>Background: Thrombosis and inflammation are crucial elements in the pathogenesis of cardiovascular disease. Hematological parameters elucidate information involving the inflammatory and blood coagulation processes. Objectives: The current study explored the association of hematological parameters with EOCAD to identify specific risk factors. Design: A single-center retrospective case–control study was conducted with 1693 coronary artery disease patients and 1693 controls. Methods: Hematological parameters were examined through an automated analyzer. Results: The basophil percentage was significantly reduced in EOCAD (0.43 ± 0.26, p &lt; 0.001) and MI (0.33 ± 0.24, p &lt; 0.001) groups compared with controls (0.54 ± 0.28). The eosinophil percentage was also significantly lower in EOCAD (2.21 ± 1.71, p &lt; 0.001) and MI (1.71 ± 2.44, p &lt; 0.001) groups compared with controls (2.41 ± 1.75). The lymphocyte percentage in patients of EOCAD and MI and controls was 31.65 ± 7.93, 25.48 ± 9.43, and 34.82 ± 7.28, respectively. A significant difference was observed among the groups (p &lt; 0.001). Except for the mean corpuscular hemoglobin (MCH), other red blood cell (RBC) parameters significantly differed between EOCAD patients and controls. The red blood cell distribution width (RDW), hematocrit (HCT), RBC count, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and hemoglobin level were associated with EOCAD prevalence after adjusting for baseline differences. Platelet volume distribution width (PDW) also correlated with EOCAD prevalence (ORadjust = 1.087, 95% CI: 1.044–1.131). Conclusions: Hematological parameters are closely associated with EOCAD. Moreover, leukocyte parameters correlated with the presence and severity of the disease. In addition, erythrocyte parameters were associated with the disease presence but not with the disease severity. Among the platelet parameters, only PDW was related to the disease presence.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>36699111</pmid><doi>10.1177/20406223221142670</doi><orcidid>https://orcid.org/0000-0001-8273-0178</orcidid><oa>free_for_read</oa></addata></record>
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subjects Blood
Cardiovascular disease
Chronic illnesses
Coronary vessels
Hematology
Hemoglobin
Original Research
Vein & artery diseases
title Hematological parameters and early-onset coronary artery disease: a retrospective case–control study based on 3366 participants
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