Reduced striatal activation in response to rewarding motor performance feedback after stroke

•Stroke patients show a reduced response of the ventral striatum to rewarding feedback.•The strong hypoactivation of nucleus accumbens could not be explained by structural damage.•Striatal hypoactivation in stroke survivors may cause impaired consolidation of motor skills. Motor skill learning can h...

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Bibliographic Details
Published in:NeuroImage clinical 2019-01, Vol.24, p.102036-102036, Article 102036
Main Authors: Widmer, Mario, Lutz, Kai, Luft, Andreas R.
Format: Article
Language:English
Subjects:
Aged
Brain Mapping
Corpus Striatum - diagnostic imaging
Corpus Striatum - physiopathology
Feedback, Psychological
Female
fMRI
Functional Laterality
Humans
Learning
Magnetic Resonance Imaging
Male
Memory Consolidation
Middle Aged
Motivation
Motor Skills
Motor tracking
Performance feedback
Psychomotor Performance
Regular
Reward
Reward processing
Striatum
Stroke
Stroke - diagnostic imaging
Stroke - psychology
Stroke Rehabilitation
Ventral Striatum - diagnostic imaging
Ventral Striatum - physiopathology
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Summary:•Stroke patients show a reduced response of the ventral striatum to rewarding feedback.•The strong hypoactivation of nucleus accumbens could not be explained by structural damage.•Striatal hypoactivation in stroke survivors may cause impaired consolidation of motor skills. Motor skill learning can help stroke survivors to cope with motor function deficits but requires many repetitions. One factor that keeps patients motivated is obtaining reward upon successfully completing a motor task. It has been suggested that stroke survivors have deficits in reward processing which may negatively impact skill learning. To test the hypothesis that stroke survivors have deficient reward processing during motor skill learning evident in reduced activation in the striatum and its subdivisions in functional magnetic resonance imaging as compared with healthy, age-matched control subjects. Striatal activity in response to performance dependent feedback and monetary reward was measured in 28 subacute stroke patients and 18 age-matched healthy control subjects during the training of visuomotor tracking an arc-shaped trajectory using the wrist (unimpaired side in patients, dominant side in controls) in an fMRI scanner. Despite comparable monetary rewards, stroke patients showed reduced activation in the ventral part (p 
ISSN:2213-1582
2213-1582
DOI:10.1016/j.nicl.2019.102036