Thyroid dysfunction in Egyptian patients with hepatitis C virus: prevalence and possible triggering

Background The contribution of chronic hepatitis C virus (HCV) infection per se in thyroid autoimmunity and dysfunction remains controversial. We investigate the prevalence of thyroid disorders and the possible association between thyroid dysfunction and different factors in a cohort of HCV-untreate...

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Bibliographic Details
Published in:The Egyptian journal of internal medicine 2019-10, Vol.31 (4), p.678-682
Main Authors: Fayed, Ahmed, Soliman, Ahmed, Naguib, Mervat, Ali, Hala M., Elhaddad, Hemmat
Format: Article
Language:English
Subjects:
Hepatitis C
hepatitis c virus
Hyperthyroidism
Hypothyroidism
Infections
Interferon
Internal Medicine
Medicine & Public Health
Original Article
thyroid
thyroid antibodies
Thyroid gland
Ultrasonic imaging
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Summary:Background The contribution of chronic hepatitis C virus (HCV) infection per se in thyroid autoimmunity and dysfunction remains controversial. We investigate the prevalence of thyroid disorders and the possible association between thyroid dysfunction and different factors in a cohort of HCV-untreated patients. Patients and methods A total 1050 patients with untreated HCV infection were enrolled in this study. Thyroid function tests, antiperoxidase (TPO-Ab), antithyroglobulin, thyroid ultrasound, real-time PCR to assess HCV RNA viral load, and fibroscan to determine degree of hepatic fibrosis were done. Results Thyroid dysfunction was found in 17.1% of patients: 11.5% hypothyroidism and 5.6% hyperthyroidism. Subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism were detected in 8.6, 2.8, 3.3, and 2.3% of patients, respectively. Thyroid ultrasound showed abnormality in 10.2% of patients. TPO-Ab and antithyroglobulin were positive in 5.1 and 6.4% of patients, respectively. TPO-Ab was more frequently positive in hyperthyroid patients compared with euthyroid ( P
ISSN:1110-7782
2090-9098
DOI:10.4103/ejim.ejim_64_19