Mini review: The role of sensory innervation to subchondral bone in osteoarthritis pain

Osteoarthritis pain is often thought of as a pain driven by nerves that innervate the soft tissues of the joint, but there is emerging evidence for a role for nerves that innervate the underlying bone. In this mini review we cite evidence that subchondral bone lesions are associated with pain in ost...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2022-12, Vol.13, p.1047943-1047943
Main Authors: Morgan, Michael, Nazemian, Vida, Harrington, Kate, Ivanusic, Jason J
Format: Article
Language:English
Subjects:
Bone and Bones - pathology
Bone Diseases
Endocrinology
Humans
neuropathy
Osteoarthritis - complications
Osteoarthritis - pathology
osteoarthritis pain
Pain - etiology
sensitization
sensory innervation
Sensory Receptor Cells - pathology
sprouting
subchondral bone
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoarthritis pain is often thought of as a pain driven by nerves that innervate the soft tissues of the joint, but there is emerging evidence for a role for nerves that innervate the underlying bone. In this mini review we cite evidence that subchondral bone lesions are associated with pain in osteoarthritis. We explore recent studies that provide evidence that sensory neurons that innervate bone are nociceptors that signal pain and can be sensitized in osteoarthritis. Finally, we describe neuronal remodeling of sensory and sympathetic nerves in bone and discuss how these processes can contribute to osteoarthritis pain.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.1047943