Hard tissue formation in pulpotomized primary teeth in dogs with nanomaterials MCM-48 and MCM-48/hydroxyapatite: an in vivo animal study

This animal study sought to evaluate two novel nanomaterials for pulpotomy of primary teeth and assess the short-term pulpal response and hard tissue formation in dogs. The results were compared with mineral trioxide aggregate (MTA). This in vivo animal study on dogs evaluated 48 primary premolar te...

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Published in:BMC oral health 2024-03, Vol.24 (1), p.322-322, Article 322
Main Authors: Talebi, Sahar, Nourbakhsh, Nosrat, Talebi, Ardeshir, Nourbakhsh, Amir Abbas, Haghighat, Abbas, Manshayi, Maziar, Bakhsheshi, Hamid Reza, Karimi, Razieh, Nazeri, Rahman, Mackenzie, Kenneth J D
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Bicuspid
Biomedical materials
Bone growth
Composite materials
Connective tissues
Dental caries
Dental pulp
Dental Pulp - pathology
Dental Pulp Capping - methods
Dentin, Secondary - pathology
Dentistry
Dogs
Drug Combinations
Drug delivery systems
Edema
Families & family life
Female
Gutta-Percha
Hard tissue formation
Health aspects
Hydroxyapatite
Hydroxyapatites
Inflammation
Inflammation - pathology
MCM-48
Nanomaterials
Nanoparticles
Nanotechnology
Osteogenesis
Oxides - pharmacology
Oxides - therapeutic use
Pediatrics
Primary teeth, mineral trioxide aggregate
Pulpotomy
Teeth
Tooth, Deciduous
Vital pulpotomy
Wound healing
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Summary:This animal study sought to evaluate two novel nanomaterials for pulpotomy of primary teeth and assess the short-term pulpal response and hard tissue formation in dogs. The results were compared with mineral trioxide aggregate (MTA). This in vivo animal study on dogs evaluated 48 primary premolar teeth of 4 mongrel female dogs the age of 6-8 weeks, randomly divided into four groups (n = 12). The teeth underwent complete pulpotomy under general anesthesia. The pulp tissue was capped with MCM-48, MCM-48/Hydroxyapatite (HA), MTA (positive control), and gutta-percha (negative control), and the teeth were restored with intermediate restorative material (IRM) paste and amalgam. After 4-6 weeks, the teeth were extracted and histologically analyzed to assess the pulpal response to the pulpotomy agent. The data were analyzed using the Kruskal‒Wallis, Fisher's exact, Spearman's, and Mann‒Whitney tests. The four groups were not significantly different regarding the severity of inflammation (P = 0.53), extent of inflammation (P = 0.72), necrosis (P = 0.361), severity of edema (P = 0.52), extent of edema (P = 0.06), or connective tissue formation (P = 0.064). A significant correlation was noted between the severity and extent of inflammation (r = 0.954, P 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-024-04098-9