Lactobacillus plantarum GMNL-662 and Lactobacillus plantarum 299v prevent osteoporosis in mice with colitis by down-regulating Akkermansia in the gut microbiome

• Published in: Journal of functional foods 2022-12, Vol.99, p.105328, Article 105328
• Main Authors: Xu, Yuhan, Xie, Qiaoling, Zhang, Wei, Zhu, Meizhen, Chen, Xiaoxuan, Guo, Dongbei, Pan, Lili, Li, Junru, Lan, Hui, Li, Hongwei
• Format: Article
• Language: English
• Subjects: Colitis; Inflammatory bowel diseases; Lactobacillus plantarum 299v; Lactobacillus plantarum GMNL-662; Osteoporosis; Probiotics
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2022.105328

In Brief: Lactobacillus plantarum GMNL-662 (Lp662) and Lactobacillus plantarum 299v (Lp299v) intervention have a protective effect on osteoporosis caused by colitis induced by DSS, partially through changes in the gut microbiota and a decrease in inflammatory factors. [Display omitted] •This study assessed the effects of probiotics on severe inflammatory bowel disease and osteoporosis.•DSS-induced colitis was used to induce osteoporosis, and short-term (21 days) intervention of probiotics Lactobacillus plantarum GMNL-662 and Lactobacillus plantarum 299v were used to explore its protective effects.•Explore the relationship between intestinal inflammation, gut microbiota, and osteoporosis.•Probiotics' therapeutic potential as an anti-inflammatory treatment to reduce bone loss was suggested. The effects of probiotics Lactobacillus plantarum GMNL-662 (Lp662) and Lactobacillus plantarum 299v (Lp299v) treatment on severe inflammatory bowel disease induced by dextran sodium sulfate was assessed. Male C57BL/6J mice (6 weeks old) were administered 0.9% NaCl, Lp662, or Lp299v by gavage during the entire experiment. After 3 weeks, gut inflammation was associated with bone loss, and compared to the control group, the weight loss caused by colitis in the Lp662 and Lp299v groups decreased (P