Genome Maintenance Mechanisms at the Chromatin Level

• Published in: International journal of molecular sciences 2021-09, Vol.22 (19), p.10384
• Main Authors: Takatsuka, Hirotomo, Shibata, Atsushi, Umeda, Masaaki
• Format: Article
• Language: English
• Subjects: Animals; Apoptosis; Ataxia; Barriers; Cell cycle; Cell death; Chromatin; Deoxyribonucleic acid; DNA; DNA damage; DNA double-strand break; DNA methylation; DNA repair; epigenetics; Gene expression; genome integrity; Genomes; Genotoxicity; Histones; Kinases; Mammals; Phosphorylation; Proteins; Radiation; Repair; Review; Stem cells
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms221910384

Genome integrity is constantly threatened by internal and external stressors, in both animals and plants. As plants are sessile, a variety of environment stressors can damage their DNA. In the nucleus, DNA twines around histone proteins to form the higher-order structure “chromatin”. Unraveling how chromatin transforms on sensing genotoxic stress is, thus, key to understanding plant strategies to cope with fluctuating environments. In recent years, accumulating evidence in plant research has suggested that chromatin plays a crucial role in protecting DNA from genotoxic stress in three ways: (1) changes in chromatin modifications around damaged sites enhance DNA repair by providing a scaffold and/or easy access to DNA repair machinery; (2) DNA damage triggers genome-wide alterations in chromatin modifications, globally modulating gene expression required for DNA damage response, such as stem cell death, cell-cycle arrest, and an early onset of endoreplication; and (3) condensed chromatin functions as a physical barrier against genotoxic stressors to protect DNA. In this review, we highlight the chromatin-level control of genome stability and compare the regulatory systems in plants and animals to find out unique mechanisms maintaining genome integrity under genotoxic stress.