The Role of MicroRNAs in Pancreatitis Development and Progression

Pancreatitis (acute and chronic) is an inflammatory disease associated with significant morbidity, including a high rate of hospitalization and mortality. MicroRNAs (miRs) are essential post-transcriptional modulators of gene expression. They are crucial in many diseases' development and progre...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-01, Vol.24 (2), p.1057
Main Authors: Patel, Hetvi R, Diaz Almanzar, Vanessa M, LaComb, Joseph F, Ju, Jingfang, Bialkowska, Agnieszka B
Format: Article
Language:English
Subjects:
Acinar cells
Acinar Cells - metabolism
Animal models
Animals
Apoptosis
Autophagy
Cytokines
Endoplasmic reticulum
Enzymes
Gene expression
Immune system
Inflammation
Inflammatory diseases
Magnetic resonance imaging
microRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Morbidity
Mortality
Pancreas
Pancreas - metabolism
Pancreas, Exocrine - metabolism
Pancreatic cancer
pancreatic stellate cells
Pancreatitis
Pancreatitis - genetics
Pancreatitis - metabolism
Post-transcription
Review
Signal transduction
Stellate cells
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Summary:Pancreatitis (acute and chronic) is an inflammatory disease associated with significant morbidity, including a high rate of hospitalization and mortality. MicroRNAs (miRs) are essential post-transcriptional modulators of gene expression. They are crucial in many diseases' development and progression. Recent studies have demonstrated aberrant miRs expression patterns in pancreatic tissues obtained from patients experiencing acute and chronic pancreatitis compared to tissues from unaffected individuals. Increasing evidence showed that miRs regulate multiple aspects of pancreatic acinar biology, such as autophagy, mitophagy, and migration, impact local and systemic inflammation and, thus, are involved in the disease development and progression. Notably, multiple miRs act on pancreatic acinar cells and regulate the transduction of signals between pancreatic acinar cells, pancreatic stellate cells, and immune cells, and provide a complex interaction network between these cells. Importantly, recent studies from various animal models and patients' data combined with advanced detection techniques support their importance in diagnosing and treating pancreatitis. In this review, we plan to provide an up-to-date summary of the role of miRs in the development and progression of pancreatitis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24021057