PPARs Signaling and Cancer in the Gastrointestinal System

Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since...

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Bibliographic Details
Published in:PPAR Research 2012-01, Vol.2012 (2012), p.476-485
Main Authors: Pazienza, Valerio, Vinciguerra, Manlio, Mazzoccoli, Gianluigi
Format: Article
Language:English
Subjects:
Apoptosis
Cancer therapies
Cyclin-dependent kinases
Gastric cancer
Hepatology
Hospitals
Kinases
Ligands
Lipids
Pancreatic cancer
Proteins
Review
Rodents
Studies
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Summary:Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.
ISSN:1687-4757
1687-4765
DOI:10.1155/2012/560846