Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

• Published in: Scientific reports 2022-12, Vol.12 (1), p.21384-21384, Article 21384
• Main Authors: Gholizadeh, Mohammad, Basafa Roodi, Poorya, Abaj, Faezeh, Shab-Bidar, Sakineh, Saedisomeolia, Ahmad, Asbaghi, Omid, lak, Mahshid
• Format: Article
• Language: English
• Subjects: 692/4017; 692/53; Adult; Biomarkers; C-reactive protein; C-Reactive Protein - analysis; Clinical trials; Dietary supplements; Dietary Supplements - analysis; Dosage; Hepatitis; Hepatitis B; Hepatitis B, Chronic; Humanities and Social Sciences; Humans; Inflammation; Inflammation - drug therapy; Interleukin 6; Meta-analysis; multidisciplinary; Oxidants; Oxidizing agents; Palmitic acid; Randomized Controlled Trials as Topic; Science; Science (multidisciplinary); Supplements; Tumor Necrosis Factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Vitamin A
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-23919-x

Vitamin A is an anti-oxidant which has been presumed to act as an anti-infective vitamin in many studies. This study aimed to evaluate the association between vitamin A supplementation and c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) levels in randomized control trials (RCTs) studies on adults. A systematic search was performed on databases including PUBMED, SCOPUS, and the Cochrane library. The studies included were considered for data extraction and subsequently assessed for effect. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were evaluated. Among 13,219 articles 13 studies were included for analysis of CRP and TNF-α, as well as 9 studies included for IL-6 in quality and quantity. The pooled WMD analysis of CRP demonstrated that vitamin A supplementation significantly increased CRP concentration with (WMD: 0.84 mg/L; 95% CI 0.29–1.39, I 2  = 0.96.2% and p value