Effects of prepubertal corticosterone treatment on urinary bladder

PURPOSE: The aim of this work was to analyze the bladder wall modifications after a chronic treatment with high doses of corticosterone in prepubertal rats. METHODS: This study included 26 male rats assigned into four groups: T30 was treated with corticosterone until 29 days of age and killed at day...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2014, Vol.29 (suppl 3), p.55-59
Main Authors: Ribeiro, Gisele S., Souza, Diogo B. De, Cortez, Célia M., Silva, Dílson, Costa, Waldemar S., Sampaio, Francisco J. B.
Format: Article
Language:English
Subjects:
Bladder
Corticosterone
Morphometry
Prepubertal
Rats
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Summary:PURPOSE: The aim of this work was to analyze the bladder wall modifications after a chronic treatment with high doses of corticosterone in prepubertal rats. METHODS: This study included 26 male rats assigned into four groups: T30 was treated with corticosterone until 29 days of age and killed at day 30, while T65 group received the same treatment but was killed at day 65. Each group had its own control group (C30 and C65). For treated animals, daily intraperitoneal injections of corticosterone (20 mg/Kg) were administered between 7th and 29th day of life. Bladders were removed and collagen, smooth muscle, elastic fibers system, vascular density and epithelium were analyzed by morphometrical methods, immunofluorescence, and biochemistry. RESULTS: Vascular density in lamina propria was reduced by 40% (p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-86502014001700011