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Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Quality of Life of Patient with History of Relapsed Acute Myeloid Leukaemia
A 52-year-old female presented to Integrated Health Options Clinic in October 2014 with a history of relapsed acute myeloid leukaemia (AML, diagnosed in 2009 and relapsed in 2014). Intravenous(IV) vitamin C therapy was initiated (in 2014) following completion of chemotherapy as an alternative to hae...
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Published in: | Antioxidants 2018-07, Vol.7 (7), p.92 |
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creator | Foster, Mike N Carr, Anitra C Antony, Alina Peng, Selene Fitzpatrick, Mike G |
description | A 52-year-old female presented to Integrated Health Options Clinic in October 2014 with a history of relapsed acute myeloid leukaemia (AML, diagnosed in 2009 and relapsed in 2014). Intravenous(IV) vitamin C therapy was initiated (in 2014) following completion of chemotherapy as an alternative to haematopoietic stem cell transplantation. IV vitamin C was administered twice weekly at a dose of 70 g/infusion. Within 4 weeks of initiation of IV vitamin C therapy, there was a dramatic improvement in the patient's blood indices with platelet cell counts increasing from 25 × 10⁸/L to 196 × 10⁸/L and white blood cell counts increasing from 0.29 × 10⁸/L to 4.0 × 10⁸/L, with further improvements observed over the next 18 months. Furthermore, there was a clear and sustained improvement in the patient's health-related quality of life scores assessed using a validated questionnaire. She has remained healthy and in complete remission until the present day. This case study highlights the benefits of IV vitamin C as a supportive therapy for previously relapsed AML. |
doi_str_mv | 10.3390/antiox7070092 |
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Intravenous(IV) vitamin C therapy was initiated (in 2014) following completion of chemotherapy as an alternative to haematopoietic stem cell transplantation. IV vitamin C was administered twice weekly at a dose of 70 g/infusion. Within 4 weeks of initiation of IV vitamin C therapy, there was a dramatic improvement in the patient's blood indices with platelet cell counts increasing from 25 × 10⁸/L to 196 × 10⁸/L and white blood cell counts increasing from 0.29 × 10⁸/L to 4.0 × 10⁸/L, with further improvements observed over the next 18 months. Furthermore, there was a clear and sustained improvement in the patient's health-related quality of life scores assessed using a validated questionnaire. She has remained healthy and in complete remission until the present day. This case study highlights the benefits of IV vitamin C as a supportive therapy for previously relapsed AML.</description><identifier>ISSN: 2076-3921</identifier><identifier>EISSN: 2076-3921</identifier><identifier>DOI: 10.3390/antiox7070092</identifier><identifier>PMID: 30012948</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>acute myeloid leukemia ; AML ; Case Report ; intravenous vitamin C ; leukemia ; vitamin C</subject><ispartof>Antioxidants, 2018-07, Vol.7 (7), p.92</ispartof><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-c077b453944c9c77720d5fa014e04c9bc8f27447172016c1cc48229896b763e53</citedby><cites>FETCH-LOGICAL-c350t-c077b453944c9c77720d5fa014e04c9bc8f27447172016c1cc48229896b763e53</cites><orcidid>0000-0002-5890-2977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070822/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070822/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30012948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foster, Mike N</creatorcontrib><creatorcontrib>Carr, Anitra C</creatorcontrib><creatorcontrib>Antony, Alina</creatorcontrib><creatorcontrib>Peng, Selene</creatorcontrib><creatorcontrib>Fitzpatrick, Mike G</creatorcontrib><title>Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Quality of Life of Patient with History of Relapsed Acute Myeloid Leukaemia</title><title>Antioxidants</title><addtitle>Antioxidants (Basel)</addtitle><description>A 52-year-old female presented to Integrated Health Options Clinic in October 2014 with a history of relapsed acute myeloid leukaemia (AML, diagnosed in 2009 and relapsed in 2014). Intravenous(IV) vitamin C therapy was initiated (in 2014) following completion of chemotherapy as an alternative to haematopoietic stem cell transplantation. IV vitamin C was administered twice weekly at a dose of 70 g/infusion. Within 4 weeks of initiation of IV vitamin C therapy, there was a dramatic improvement in the patient's blood indices with platelet cell counts increasing from 25 × 10⁸/L to 196 × 10⁸/L and white blood cell counts increasing from 0.29 × 10⁸/L to 4.0 × 10⁸/L, with further improvements observed over the next 18 months. Furthermore, there was a clear and sustained improvement in the patient's health-related quality of life scores assessed using a validated questionnaire. She has remained healthy and in complete remission until the present day. This case study highlights the benefits of IV vitamin C as a supportive therapy for previously relapsed AML.</description><subject>acute myeloid leukemia</subject><subject>AML</subject><subject>Case Report</subject><subject>intravenous vitamin C</subject><subject>leukemia</subject><subject>vitamin C</subject><issn>2076-3921</issn><issn>2076-3921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkc1uEzEUhS1ERavSJVvkFxjw34zHG6QwoiRSELQqbC2PfxoXjx3NeAJ5GZ4Vp4Gq8eZY99z7XcsHgDcYvaNUoPcqZp9-c8QREuQFuCCINxUVBL98dj8HV9P0gMoRmLZIvALnFCFMBGsvwJ9VzKPa2ZjmCf7wWQ0-wg4uTFE_FassiHA1bMe0swZ-DCkZ2NkQYJfmmCeoooFLq0LeVLc2qFyabmYVfN7D5ODaO3vQb4VjY4a_fN7AZQGn8dE_jGynMrPQc7bwy96G5A1c2_mnsoNXr8GZU2GyV__0Eny__nTXLav118-rbrGuNK1RrjTivGc1FYxpoTnnBJnaKYSZRaXS69YRzhjHxcCNxlqzlhDRiqbnDbU1vQSrI9ck9SC3ox_UuJdJeflYSOO9VGP2OlgpCky0rq-ZcEwj3DdMGadq3CqkSdMX1ocjazv3gzXaHn44nEBPneg38j7tZFNyLM8qgOoI0GOaptG6p1mM5CF3eZJ76X_7fOFT9_-U6V8-raxw</recordid><startdate>20180716</startdate><enddate>20180716</enddate><creator>Foster, Mike N</creator><creator>Carr, Anitra C</creator><creator>Antony, Alina</creator><creator>Peng, Selene</creator><creator>Fitzpatrick, Mike G</creator><general>MDPI</general><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5890-2977</orcidid></search><sort><creationdate>20180716</creationdate><title>Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Quality of Life of Patient with History of Relapsed Acute Myeloid Leukaemia</title><author>Foster, Mike N ; Carr, Anitra C ; Antony, Alina ; Peng, Selene ; Fitzpatrick, Mike G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-c077b453944c9c77720d5fa014e04c9bc8f27447172016c1cc48229896b763e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>acute myeloid leukemia</topic><topic>AML</topic><topic>Case Report</topic><topic>intravenous vitamin C</topic><topic>leukemia</topic><topic>vitamin C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foster, Mike N</creatorcontrib><creatorcontrib>Carr, Anitra C</creatorcontrib><creatorcontrib>Antony, Alina</creatorcontrib><creatorcontrib>Peng, Selene</creatorcontrib><creatorcontrib>Fitzpatrick, Mike G</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Antioxidants</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foster, Mike N</au><au>Carr, Anitra C</au><au>Antony, Alina</au><au>Peng, Selene</au><au>Fitzpatrick, Mike G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Quality of Life of Patient with History of Relapsed Acute Myeloid Leukaemia</atitle><jtitle>Antioxidants</jtitle><addtitle>Antioxidants (Basel)</addtitle><date>2018-07-16</date><risdate>2018</risdate><volume>7</volume><issue>7</issue><spage>92</spage><pages>92-</pages><issn>2076-3921</issn><eissn>2076-3921</eissn><abstract>A 52-year-old female presented to Integrated Health Options Clinic in October 2014 with a history of relapsed acute myeloid leukaemia (AML, diagnosed in 2009 and relapsed in 2014). Intravenous(IV) vitamin C therapy was initiated (in 2014) following completion of chemotherapy as an alternative to haematopoietic stem cell transplantation. IV vitamin C was administered twice weekly at a dose of 70 g/infusion. Within 4 weeks of initiation of IV vitamin C therapy, there was a dramatic improvement in the patient's blood indices with platelet cell counts increasing from 25 × 10⁸/L to 196 × 10⁸/L and white blood cell counts increasing from 0.29 × 10⁸/L to 4.0 × 10⁸/L, with further improvements observed over the next 18 months. Furthermore, there was a clear and sustained improvement in the patient's health-related quality of life scores assessed using a validated questionnaire. She has remained healthy and in complete remission until the present day. This case study highlights the benefits of IV vitamin C as a supportive therapy for previously relapsed AML.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>30012948</pmid><doi>10.3390/antiox7070092</doi><orcidid>https://orcid.org/0000-0002-5890-2977</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | acute myeloid leukemia AML Case Report intravenous vitamin C leukemia vitamin C |
title | Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Quality of Life of Patient with History of Relapsed Acute Myeloid Leukaemia |
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