Conventional and novel stem cell based therapies for androgenic alopecia

The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription...

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Bibliographic Details
Published in:Stem cells and cloning 2017-01, Vol.10, p.11-19
Main Authors: Talavera-Adame, Dodanim, Newman, Daniella, Newman, Nathan
Format: Article
Language:English
Subjects:
Alopecia
androgenic alopecia
Blood platelets
Care and treatment
Cell cycle
dermal papilla cells
Dermatology
FDA approval
Fibroblasts
Growth factors
hair follicle
Hair follicles
hair growth
Hair loss
Health aspects
Kinases
laser therapy
Medical research
Methods
Morphogenesis
Physiological aspects
Plasma
Regenerative medicine
Review
stem cell therapy
Stem cell transplantation
Stem cells
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Description
Summary:The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits. Biologic factors that include signaling from stem cells, dermal papilla cells, and platelet-rich plasma are some of the current therapeutic agents being studied for hair restoration with milder side effects. However, most of the mechanisms exerted by these factors in hair restoration are still being researched. In this review, we analyze the therapeutic agents that have been used for AGA and emphasize the potential of new therapies based on advances in stem cell technologies and regenerative medicine.
ISSN:1178-6957
1178-6957
DOI:10.2147/SCCAA.S138150