IgE-Mediated Fish Allergy in Children

Fish allergy constitutes a severe problem worldwide. Its prevalence has been calculated as high as 7% in paediatric populations, and in many cases, it persists into adulthood with life-threatening signs and symptoms. The following review focuses on the epidemiology of Immunoglobulin E (IgE)-mediated...

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Published in:Medicina (Kaunas, Lithuania) Lithuania), 2021-01, Vol.57 (1), p.76
Main Authors: Buyuktiryaki, Betul, Masini, Marzio, Mori, Francesca, Barni, Simona, Liccioli, Giulia, Sarti, Lucrezia, Lodi, Lorenzo, Giovannini, Mattia, du Toit, George, Lopata, Andreas Ludwig, Marques-Mejias, Maria Andreina
Format: Article
Language:English
Subjects:
Adult
allergen
Allergens
Animals
basophil activation test
Child
component resolved diagnosis
fish allergy
Fishes
Food Hypersensitivity - diagnosis
Food Hypersensitivity - epidemiology
Food Hypersensitivity - therapy
Humans
Immunoglobulin E
management
Parvalbumins
Review
Skin Tests
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Summary:Fish allergy constitutes a severe problem worldwide. Its prevalence has been calculated as high as 7% in paediatric populations, and in many cases, it persists into adulthood with life-threatening signs and symptoms. The following review focuses on the epidemiology of Immunoglobulin E (IgE)-mediated fish allergy, its pathogenesis, clinical manifestations, and a thorough approach to diagnosis and management in the paediatric population. The traditional approach for managing fish allergy is avoidance and rescue medication for accidental exposures. Food avoidance poses many obstacles and is not easily maintained. In the specific case of fish, food is also not the only source of allergens; aerosolisation of fish proteins when cooking is a common source of highly allergenic parvalbumin, and elimination diets cannot prevent these contacts. Novel management approaches based on immunomodulation are a promising strategy for the future of these patients.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina57010076