Degree of Blood Pressure Control and Incident Diabetes Mellitus in Chinese Adults With Hypertension

Background The association between blood pressure (BP) control and incident diabetes mellitus remains unknown. We aim to investigate the association between degree of time-averaged on-treatment systolic blood pressure (SBP) control and incident diabetes mellitus in hypertensive adults. Methods and R...

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Bibliographic Details
Published in:Journal of the American Heart Association 2020-08, Vol.9 (16), p.e017015-e017015
Main Authors: Zhang, Yuanyuan, Nie, Jing, Zhang, Yan, Li, Jianping, Liang, Min, Wang, Guobao, Tian, Jianwei, Liu, Chengzhang, Wang, Binyan, Cui, Yimin, Wang, Xiaobin, Huo, Yong, Xu, Xiping, Hou, Fan Fan, Qin, Xianhui
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - therapeutic use
Blood Pressure Determination
China - epidemiology
degree of blood pressure control
Diabetes Mellitus - blood
Diabetes Mellitus - diagnosis
Diabetes Mellitus - drug therapy
Diabetes Mellitus - epidemiology
Double-Blind Method
Enalapril - therapeutic use
Fasting - blood
Female
Folic Acid - therapeutic use
Humans
hypertension
Hypertension - drug therapy
Hypoglycemic Agents - therapeutic use
Incidence
incident diabetes mellitus
Male
Middle Aged
Odds Ratio
Original Research
Propensity Score
regression to normal fasting glucose
Risk
systolic blood pressure
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Summary:Background The association between blood pressure (BP) control and incident diabetes mellitus remains unknown. We aim to investigate the association between degree of time-averaged on-treatment systolic blood pressure (SBP) control and incident diabetes mellitus in hypertensive adults. Methods and Results A total of 14 978 adults with hypertension without diabetes mellitus at baseline were included from the CSPPT (China Stroke Primary Prevention Trial). Participants were randomized double-masked to daily enalapril 10 mg and folic acid 0.8 mg or enalapril 10 mg alone. BP measurements were taken every 3 months after randomization. The primary outcome was incident diabetes mellitus, defined as physician-diagnosed diabetes mellitus, or use of glucose-lowering drugs during follow-up, or fasting glucose ≥126 mg/dL at the exit visit. Over a median of 4.5 years, a significantly higher risk of incident diabetes mellitus was found in participants with time-averaged on-treatment SBP 130 to
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.120.017015