Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review

• Published in: Marine drugs 2025-01, Vol.23 (1), p.43
• Main Authors: Santi Martignago, Cintia Cristina, de Souza Barbosa, Camila, Garcia Motta, Homero, Soares-Silva, Beatriz, Maso Lopes Peres, Erica Paloma, Souza E Silva, Lais Caroline, Bonifácio, Mirian, Dos Santos Jorge Sousa, Karolyne, Sardeli Alqualo, Amanda, Parisi, Júlia, Jordan, Olivier, Muniz Renno, Ana Claudia, Aguiar, Anna Caroline Campos, Patrulea, Viorica
• Format: Article
• Language: English
• Subjects: Alkaloids - chemistry; Alkaloids - pharmacology; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibacterial; Antibacterial activity; Antibiotics; Antimicrobial activity; Antimicrobial agents; Aquatic Organisms; Biological Products - chemistry; Biological Products - pharmacology; Chemical activity; Chemical defense; Disease resistance; Drug development; Drug Resistance, Multiple, Bacterial - drug effects; Drugs; Humans; Islands; Literature reviews; Marine invertebrates; marine sponge; Metabolites; Microbial Sensitivity Tests; Minimum inhibitory concentration; Multidrug resistance; multidrug-resistant; natural product; Natural products; P. aeruginosa; Pathogens; Pharmaceutical industry; Pharmacology; Porifera; Predators; Pseudomonas aeruginosa - drug effects; Reviews; Secondary metabolites; Sesterterpenoids; Systematic Review; Viral infections
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md23010043

The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting , a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents.