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Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review
The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge...
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| Published in: | Marine drugs 2025-01, Vol.23 (1), p.43 |
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| container_title | Marine drugs |
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| creator | Santi Martignago, Cintia Cristina de Souza Barbosa, Camila Garcia Motta, Homero Soares-Silva, Beatriz Maso Lopes Peres, Erica Paloma Souza E Silva, Lais Caroline Bonifácio, Mirian Dos Santos Jorge Sousa, Karolyne Sardeli Alqualo, Amanda Parisi, Júlia Jordan, Olivier Muniz Renno, Ana Claudia Aguiar, Anna Caroline Campos Patrulea, Viorica |
| description | The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting
, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents. |
| doi_str_mv | 10.3390/md23010043 |
| format | article |
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, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. 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This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting
, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. 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This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting
, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39852545</pmid><doi>10.3390/md23010043</doi><orcidid>https://orcid.org/0000-0003-4902-513X</orcidid><orcidid>https://orcid.org/0000-0002-4325-0638</orcidid><orcidid>https://orcid.org/0000-0003-3752-2198</orcidid><orcidid>https://orcid.org/0000-0003-3906-2041</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alkaloids - chemistry Alkaloids - pharmacology Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial Antibacterial activity Antibiotics Antimicrobial activity Antimicrobial agents Aquatic Organisms Biological Products - chemistry Biological Products - pharmacology Chemical activity Chemical defense Disease resistance Drug development Drug Resistance, Multiple, Bacterial - drug effects Drugs Humans Islands Literature reviews Marine invertebrates marine sponge Metabolites Microbial Sensitivity Tests Minimum inhibitory concentration Multidrug resistance multidrug-resistant natural product Natural products P. aeruginosa Pathogens Pharmaceutical industry Pharmacology Porifera Predators Pseudomonas aeruginosa - drug effects Reviews Secondary metabolites Sesterterpenoids Systematic Review Viral infections |
| title | Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review |
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