Comparison of the FRIEND and Wasserman-Hansen Equations in Predicting Outcomes in Heart Failure

Background Percentage of age-predicted peak oxygen uptake (VO ) achieved (ppVO ) has been widely used to stratify risk in patients with heart failure. However, there are limitations to traditional normal standards. We compared the recently derived FRIEND (Fitness Registry and the Importance of Exerc...

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Bibliographic Details
Published in:Journal of the American Heart Association 2021-11, Vol.10 (21), p.e021246-e021246
Main Authors: Myers, Jonathan, de Souza E Silva, Christina G, Arena, Ross, Kaminsky, Leonard, Christle, Jeffrey W, Busque, Vincent, Ashley, Euan, Moneghetti, Kegan
Format: Article
Language:English
Subjects:
Adult
Aged
cardiorespiratory fitness
Exercise
Exercise Test
exercise testing
heart failure
Heart Failure - diagnosis
Humans
Middle Aged
Original Research
outcomes
Oxygen Consumption
oxygen uptake
Registries
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Summary:Background Percentage of age-predicted peak oxygen uptake (VO ) achieved (ppVO ) has been widely used to stratify risk in patients with heart failure. However, there are limitations to traditional normal standards. We compared the recently derived FRIEND (Fitness Registry and the Importance of Exercise: A National Data Base) equation to the widely used Wasserman-Hansen (WH) ppVO equation to predict outcomes in patients with heart failure. Methods and Results A subgroup of 4055 heart failure patients from the FRIEND registry (mean age 53±15 years) was followed for a mean of 28±16 months. The FRIEND and WH equations along with measured peak VO expressed in mL/kg per min were compared for mortality and composite cardiovascular events. ppVO was higher for the FRIEND versus the WH equation (66±30% versus 58±25%;
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.121.021246