Oxford brain health clinic: protocol and research database

IntroductionDespite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research s...

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Bibliographic Details
Published in:BMJ open 2023-08, Vol.13 (8), p.e067808-e067808
Main Authors: O'Donoghue, Melissa Clare, Blane, Jasmine, Gillis, Grace, Mitchell, Robert, Lindsay, Karen, Semple, Juliet, Pretorius, Pieter M, Griffanti, Ludovica, Fossey, Jane, Raymont, Vanessa, Martos, Lola, Mackay, Clare E
Format: Article
Language:English
Subjects:
Accreditation
Biomarkers
Brain - diagnostic imaging
Brain research
Clinical medicine
Clinical Protocols
Consent
Contraindications
Dementia
Humans
Magnetic Resonance Imaging
Medical imaging
Memory
Memory Disorders
Neuroimaging
Neurology
Old age psychiatry
Patients
Psychiatrists
PSYCHIATRY
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Summary:IntroductionDespite major advances in the field of neuroscience over the last three decades, the quality of assessments available to patients with memory problems in later life has barely changed. At the same time, a large proportion of dementia biomarker research is conducted in selected research samples that often poorly reflect the demographics of the population of patients who present to memory clinics. The Oxford Brain Health Clinic (BHC) is a newly developed clinical assessment service with embedded research in which all patients are offered high-quality clinical and research assessments, including MRI, as standard.Methods and analysisHere we describe the BHC protocol, including aligning our MRI scans with those collected in the UK Biobank. We evaluate rates of research consent for the first 108 patients (data collection ongoing) and the ability of typical psychiatry-led NHS memory-clinic patients to tolerate both clinical and research assessments.Ethics and disseminationOur ethics and consenting process enables patients to choose the level of research participation that suits them. This generates high rates of consent, enabling us to populate a research database with high-quality data that will be disseminated through a national platform (the Dementias Platform UK data portal).
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-067808