Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia

We used a lentiviral vector bearing the viral spike protein to detect neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) in persons from the Eastern Province of Saudi Arabia. None of the 268 samples tested displayed neutralizing activity, which suggests that MERS...

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Bibliographic Details
Published in:Emerging infectious diseases 2013-12, Vol.19 (12), p.2034-2036
Main Authors: Gierer, Stefanie, Hofmann-Winkler, Heike, Albuali, Waleed H, Bertram, Stephanie, Al-Rubaish, Abdullah M, Yousef, Abdullah A, Al-Nafaie, Awatif N, Al-Ali, Amein K, Obeid, Obeid E, Alkharsah, Khaled R, Pöhlmann, Stefan
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
Coronavirus - immunology
Coronavirus Infections - epidemiology
Coronavirus Infections - immunology
Coronavirus Infections - transmission
Dispatch
Female
Health aspects
Humans
Infection
Male
MERS coronavirus
MERS-CoV
Middle Aged
neutralizing antibodies
pseudotyping
Saudi Arabia
Saudi Arabia - epidemiology
Seroepidemiologic Studies
spike
Viral antibodies
Young Adult
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Summary:We used a lentiviral vector bearing the viral spike protein to detect neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) in persons from the Eastern Province of Saudi Arabia. None of the 268 samples tested displayed neutralizing activity, which suggests that MERS-CoV infections in humans are infrequent in this province.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1912.130701