Delayed peak of human infections and ongoing reassortment of H7N9 avian influenza virus in the newly affected western Chinese provinces during Wave Five

• Published in: International journal of infectious diseases 2019-11, Vol.88, p.80-87
• Main Authors: Li, Jin, Chen, Chuming, Wei, Jinli, Huang, Huaxin, Peng, Yun, Bi, Yuhai, Liu, Yingxia, Yang, Yang
• Format: Article
• Language: English
• Subjects: Avian influenza virus (AIV); China - epidemiology; Disease Outbreaks; Genome, Viral; Genotype; H7N9; Humans; Influenza A Virus, H7N9 Subtype - classification; Influenza A Virus, H7N9 Subtype - genetics; Influenza A Virus, H7N9 Subtype - isolation & purification; Influenza, Human - epidemiology; Influenza, Human - virology; Phylogeny; Reassortment; Wave Five; Western dissemination
• ISSN: 1201-9712; 1878-3511
• DOI: 10.1016/j.ijid.2019.09.002

•The epidemiological and virological characteristics of H7N9 avian influenza virus in the newly affected western Chinese provinces were analyzed.•A delayed peak of human infections was observed.•G11 and G3 were the dominant genotypes of prevalent low pathogenic (LP)- and highly pathogenic (HP)-H7N9 virus, respectively.•Reassortment has been ongoing. Eight additional provinces in western China reported human infections for the first time during the fifth wave of human H7N9 infections. The aim of this study was to analyze the epidemiological and virological characteristics of this outbreak. The epidemiological data of H7N9 cases from the newly affected western Chinese provinces were collected and analyzed. Full-length genome sequences of H7N9 virus were downloaded from the GenBank and GISAID databases, and phylogenetic, genotyping, and genetic analyses were conducted. The peak of human infections in the newly affected western Chinese provinces was delayed by 4 months compared to the eastern Chinese provinces, and both low pathogenic (LP) and highly pathogenic (HP) H7N9-infected cases were found. The LP- and HP-H7N9 virus belonged to 10 different genotypes (including four new genotypes), of which G11 and G3 were the dominant genotypes, respectively. Almost all of these viruses originated from eastern and southern China and were most probably imported from neighboring provinces. Genetic characteristics of the circulating viruses were similar to those of the viruses from previously affected provinces during Wave Five. A delayed peak of human infections was observed in the newly affected western Chinese provinces, and reassortment has been ongoing since the introduction of H7N9 viruses. This study highlights the importance of continued surveillance of the circulation and evolution of H7N9 virus in western China.