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Dataset of immune responses induced in swine by an inactivated Porcine Circovirus 2b vaccine
A whole virus, inactivated, Porcine Circovirus 2b (PCV2b) vaccine was submitted to a quantal assay of potency, as explained in detail in our companion paper [1]. To this purpose, twenty, 45-day old piglets, checked for maternally-derived antibody (MDA), were allocated to four groups of 5 animals eac...
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Published in: | Data in brief 2021-04, Vol.35, p.106906-106906, Article 106906 |
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description | A whole virus, inactivated, Porcine Circovirus 2b (PCV2b) vaccine was submitted to a quantal assay of potency, as explained in detail in our companion paper [1]. To this purpose, twenty, 45-day old piglets, checked for maternally-derived antibody (MDA), were allocated to four groups of 5 animals each; these were vaccinated with 800/266/88/0 nanograms, respectively, of an inactivated PCV2b strain, consisting of two distinct virion populations. Twenty-six days later, all the pigs were challenged intranasally with the homologous PCV2b strain. In the presence of a clear dose-dependent protection in terms of viremia, no such effect was observed in terms of weight gain after challenge. The 800 and 266-ng payloads were associated with neutralizing antibody titers above the MDA levels in oral fluids. Higher levels of viremia in control and 88-ng groups [1] coincided with a higher Natural Killer activity of tracheobronchial lymph node cells from PCV2-infected pigs. The PCV2 ORF2-specific ELISPOT assay for IFN-g– secreting cells showed very few (2–4) ORF2-specific cells/105 peripheral blood mononuclear cells beyond the basal levels under our experimental conditions (non-significant differences among groups). Also, no significant differences were observed in the degree of lymphoid tissue hyperplasia among the different groups. |
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The PCV2 ORF2-specific ELISPOT assay for IFN-g– secreting cells showed very few (2–4) ORF2-specific cells/105 peripheral blood mononuclear cells beyond the basal levels under our experimental conditions (non-significant differences among groups). Also, no significant differences were observed in the degree of lymphoid tissue hyperplasia among the different groups.</description><identifier>ISSN: 2352-3409</identifier><identifier>EISSN: 2352-3409</identifier><identifier>DOI: 10.1016/j.dib.2021.106906</identifier><identifier>PMID: 33997189</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Cell-mediated immunity ; Data ; Neutralizing antibody ; Pig ; Porcine Circovirus 2 ; Vaccine ; Weight gain</subject><ispartof>Data in brief, 2021-04, Vol.35, p.106906-106906, Article 106906</ispartof><rights>2021</rights><rights>2021 The Author(s). Published by Elsevier Inc.</rights><rights>2021 The Author(s). 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The PCV2 ORF2-specific ELISPOT assay for IFN-g– secreting cells showed very few (2–4) ORF2-specific cells/105 peripheral blood mononuclear cells beyond the basal levels under our experimental conditions (non-significant differences among groups). 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The PCV2 ORF2-specific ELISPOT assay for IFN-g– secreting cells showed very few (2–4) ORF2-specific cells/105 peripheral blood mononuclear cells beyond the basal levels under our experimental conditions (non-significant differences among groups). Also, no significant differences were observed in the degree of lymphoid tissue hyperplasia among the different groups.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>33997189</pmid><doi>10.1016/j.dib.2021.106906</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Cell-mediated immunity Data Neutralizing antibody Pig Porcine Circovirus 2 Vaccine Weight gain |
title | Dataset of immune responses induced in swine by an inactivated Porcine Circovirus 2b vaccine |
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