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Dataset of immune responses induced in swine by an inactivated Porcine Circovirus 2b vaccine

A whole virus, inactivated, Porcine Circovirus 2b (PCV2b) vaccine was submitted to a quantal assay of potency, as explained in detail in our companion paper [1]. To this purpose, twenty, 45-day old piglets, checked for maternally-derived antibody (MDA), were allocated to four groups of 5 animals eac...

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Published in:Data in brief 2021-04, Vol.35, p.106906-106906, Article 106906
Main Authors: Guarneri, Flavia, Tresoldi, Enrico Tommaso, Sarli, Giuseppe, Boniotti, Maria Beatrice, Lelli, Davide, Barbieri, Ilaria, Bacci, Barbara, D'Annunzio, Giulia, Amadori, Massimo
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container_title Data in brief
container_volume 35
creator Guarneri, Flavia
Tresoldi, Enrico Tommaso
Sarli, Giuseppe
Boniotti, Maria Beatrice
Lelli, Davide
Barbieri, Ilaria
Bacci, Barbara
D'Annunzio, Giulia
Amadori, Massimo
description A whole virus, inactivated, Porcine Circovirus 2b (PCV2b) vaccine was submitted to a quantal assay of potency, as explained in detail in our companion paper [1]. To this purpose, twenty, 45-day old piglets, checked for maternally-derived antibody (MDA), were allocated to four groups of 5 animals each; these were vaccinated with 800/266/88/0 nanograms, respectively, of an inactivated PCV2b strain, consisting of two distinct virion populations. Twenty-six days later, all the pigs were challenged intranasally with the homologous PCV2b strain. In the presence of a clear dose-dependent protection in terms of viremia, no such effect was observed in terms of weight gain after challenge. The 800 and 266-ng payloads were associated with neutralizing antibody titers above the MDA levels in oral fluids. Higher levels of viremia in control and 88-ng groups [1] coincided with a higher Natural Killer activity of tracheobronchial lymph node cells from PCV2-infected pigs. The PCV2 ORF2-specific ELISPOT assay for IFN-g– secreting cells showed very few (2–4) ORF2-specific cells/105 peripheral blood mononuclear cells beyond the basal levels under our experimental conditions (non-significant differences among groups). Also, no significant differences were observed in the degree of lymphoid tissue hyperplasia among the different groups.
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subjects Cell-mediated immunity
Data
Neutralizing antibody
Pig
Porcine Circovirus 2
Vaccine
Weight gain
title Dataset of immune responses induced in swine by an inactivated Porcine Circovirus 2b vaccine
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