Blood Plasma Thermograms Dataset Analysisby Means of InterCriteria and Correlation Analyses for the Case of Colorectal Cancer

The approaches of InterCriteria Analysis and Correlation Analysis are applied to a dataset of calorimetric and statistical parameters obtained from blood plasma proteome thermograms of colorectal cancer patients. The analysis was performed for four individual predefined subsets of calorimetric profi...

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Bibliographic Details
Published in:Bioautomation 2016-03, Vol.20 (1), p.115-124
Main Authors: Todinova, Svetla, Mavrov, Deyan, Krumova, Sashka, Marinov, Pencho, Atanassova, Vassia, Atanassov, Krassimir, Taneva, Stefka G
Format: Article
Language:English
Subjects:
Colorectal cancer
Correlation Đ°nalysis
Differential scanning calorimetry
Immunoglobulins
InterCriteria analysis
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Summary:The approaches of InterCriteria Analysis and Correlation Analysis are applied to a dataset of calorimetric and statistical parameters obtained from blood plasma proteome thermograms of colorectal cancer patients. The analysis was performed for four individual predefined subsets of calorimetric profiles. Specific interrelations between the studied criteria were identified that were found to differ among the different calorimetric subsets. For three of the subsets the enthalpy of the thermal profiles was in strong consonance with the excess heat capacity of the immunoglobulins assigned thermal transition. For the calorimetric subsets that differed most from the control healthy set a strong interrelation between the excess heat capacities of the main plasma proteins (albumin and immunoglobulins) was additionally evident. Our results demonstrate that these mathematical approaches can complement the analysis of calorimetric datasets generated for a variety of diseases.
ISSN:1314-1902
1314-2321