Dietary Supplemented Anthocyanin Reduced Serum Amyloid Beta Oligomers and Improved Cognitive Dysfunction Scores in Elderly Dogs

Like humans, the accumulation of amyloid-beta oligomers in the brains of aged dogs leads to cognitive dysfunction. Our study investigated the effects of dietary flavonoids in pet foods on cognitive dysfunction. All nine dogs (six species) recruited were older than seven years, and cognitive function...

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Bibliographic Details
Published in:Applied sciences 2022-12, Vol.12 (23), p.12130
Main Authors: Lee, Mi-Jin, Park, Miey, Lee, Hae-Jeung
Format: Article
Language:English
Subjects:
Abnormalities
Alzheimer's disease
Animal cognition
Anthocyanins
Biomarkers
Blood tests
Body temperature
Chemistry
Cognitive ability
cognitive dysfunction score
cyanidin-3-O-glucoside
Dogs
Electrolytes
Flavonoids
Food
Heart rate
Laboratory animals
pet food
Petfoods
Pets
Questionnaires
Respiration
Respiratory rate
serum AβO
Statistical analysis
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Summary:Like humans, the accumulation of amyloid-beta oligomers in the brains of aged dogs leads to cognitive dysfunction. Our study investigated the effects of dietary flavonoids in pet foods on cognitive dysfunction. All nine dogs (six species) recruited were older than seven years, and cognitive function was measured using a questionnaire before and after applying pet food containing cyanidin-3-O-glucoside, the main component of honeyberries. Physical examination, blood tests, cognitive dysfunction scores, and serum amyloid-beta oligomers were measured. After 90 days of pet food administration, a physical examination revealed no abnormalities in weight, body temperature, heart rate, or respiratory rate. However, the cognitive dysfunction score and serum amyloid-beta oligomers (AβO) marker levels were significantly reduced after 90 days. Inflammation and antioxidant levels were slightly, but not significantly, changed. Our results suggest that pet food containing anthocyanins effectively improves cognitive dysfunction scores and decreases serum AβO levels.
ISSN:2076-3417
2076-3417
DOI:10.3390/app122312130