The association between urinary phthalate metabolites and serum thyroid function in US adolescents

The aim was to investigate the association between mixed exposure to phthalates and serum thyroid function among US adolescents. The study used 2007–2008 survey data from the National Health and Nutrition Examination Survey (NHANES). Data on urinary phthalates metabolites and serum thyroid function...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2023-07, Vol.13 (1), p.11601-11601, Article 11601
Main Authors: Xiang, Shi-ting, Cao, Yuhan, Dong, Jie, Li, Chao, Qiu, Jun, Li, Xun
Format: Article
Language:English
Subjects:
692/163
692/53
Adolescent
Adolescents
Bayes Theorem
Bayesian analysis
Environmental Exposure - adverse effects
Environmental Exposure - analysis
Environmental Pollutants - analysis
Humanities and Social Sciences
Humans
Mathematical models
Metabolites
multidisciplinary
Nutrition Surveys
Phthalate esters
Phthalates
Phthalic Acids - metabolism
Regression analysis
Science
Science (multidisciplinary)
Surveys
Teenagers
Thyroid
Thyroid gland
Thyroid Gland - metabolism
Thyroid hormones
Thyroid-stimulating hormone
Thyrotropin
Triiodothyronine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim was to investigate the association between mixed exposure to phthalates and serum thyroid function among US adolescents. The study used 2007–2008 survey data from the National Health and Nutrition Examination Survey (NHANES). Data on urinary phthalates metabolites and serum thyroid function indicators were collected. The weighted multivariable linear regression models and Bayesian kernel machine regression (BKMR) analyses were used to analyze the relationship between phthalates metabolites and thyroid function. A total of 356 adolescents aged 12–19 years were included in the analysis. Linear regression models showed that mono-(carboxyisoctyl) phthalate (MCOP) was positively correlated with total triiodothyronine (TT3) (β = 0.045, 95% confidence interval [CI] 0.022, 0.068) and thyroid stimulating hormone (TSH) (β = 0.1461, 95% CI 0.059, 0.232), while mono-(carboxyisononyl) phthalate (MCNP) was negatively correlated with TSH (β = − 0.119, 95% CI − 0.196, − 0.042). BKMR analyses showed phthalate metabolites mixtures have significantly positive overall effect on TT3. Exposure to phthalate mixtures might be positively correlated with increased TT3 serum level in US adolescents. The study provided evidence for the association between mixed phthalates exposure and thyroid health in adolescent population.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-38644-2