Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study

The current study aimed to investigate whether serum RBP levels can be a key predictor of peripartum depression (PPD). This was a prospective cohort study, conducted at a general teaching hospital in South China. Research participants were evaluated at three time points: the third trimester of pregn...

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Bibliographic Details
Published in:BMC psychiatry 2017-08, Vol.17 (1), p.278-278, Article 278
Main Authors: Zeng, Yingchun, Li, Yingtao, Xia, Huaan, Wang, Shenglan, Zhou, Jingxuan, Chen, Dunjin
Format: Article
Language:English
Subjects:
17β-Estradiol
Adult
Analysis
Anxiety
Anxiety Disorders - blood
Anxiety Disorders - epidemiology
Binding proteins
Child
China - epidemiology
Chinese women
Cohort analysis
Cohort Studies
Data processing
Depression (Mood disorder)
Depression, Postpartum - blood
Depression, Postpartum - epidemiology
Diagnosis
Female
Health risk assessment
Humans
Maternal health services
Measurement
Mental depression
Peripartum depression
Peripartum Period
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - epidemiology
Pregnancy Trimester, Third
Prevalence
Prospective Studies
Psychiatry
Retinoids
Retinoids - blood
Retinol-binding protein
Surveys and Questionnaires
Vitamin A
Womens health
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Summary:The current study aimed to investigate whether serum RBP levels can be a key predictor of peripartum depression (PPD). This was a prospective cohort study, conducted at a general teaching hospital in South China. Research participants were evaluated at three time points: the third trimester of pregnancy (T1), after delivery at week one (T2), and after delivery week six (T3) using a set of self-reported questionnaires and blood sample assays. A total of 156 subjects were included for data analysis. The prevalence of anxiety symptoms ranged from 32.69% to 36.53%. The prevalence of PPD was also high and ranged from 27.56% to 35.89%. In the third trimester, significant predictors of depressive symptoms include serum retinol-binding protein (RBP) concentrations and estradiol levels (P = 0.008 and 0.033, respectively). At one week after delivery, serum concentrations of RBP at T2 were still significant predictors of depressive symptoms (P = 0.020, and serum estradiol concentrations at T1 were a significant predictor (P = 0.010). The most stable predictor of depressive symptoms at T3 was anxiety symptoms, especially at T3 time point (P 
ISSN:1471-244X
1471-244X
DOI:10.1186/s12888-017-1405-0