Evaluation of ascitic soluble human leukocyte antigen-G for distinguishing malignant ascites from benign ascites

• Published in: Tumor biology 2017-11, Vol.39 (11), p.1010428317726840-1010428317726840
• Main Authors: Sun, Juan, Chang, Yan-Xiang, Niu, Chun-Yan
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antigens; Area Under Curve; Ascites; Ascites - complications; Ascites - diagnosis; Ascites - etiology; Benign; Biomarkers, Tumor - analysis; Biopsy; Breast cancer; Cancer therapies; Carbohydrates; Carcinoembryonic antigen; Cellular biology; Colorectal cancer; Cytology; Enzyme-linked immunosorbent assay; Family medical history; Female; Gastric cancer; Histocompatibility antigen HLA; HLA-G Antigens - analysis; Hospitals; Humans; Laboratories; Lung cancer; Male; Medical prognosis; Middle Aged; Neoplasms - complications; Neoplasms - diagnosis; Neuroblastoma; Ovarian cancer; ROC Curve; Sensitivity; Sensitivity and Specificity; Tumors
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1177/1010428317726840

The overexpression of soluble human leukocyte antigen-G is associated with malignant tumours. The purpose of our study was to detect soluble human leukocyte antigen-G concentrations in ascites and to evaluate the value of ascitic soluble human leukocyte antigen-G for the diagnosis of malignant ascites. Enzyme-linked immunosorbent assay was used to detect soluble human leukocyte antigen-G levels in 64 patients with malignant ascites and 30 patients with benign ascites. Receiver operating characteristic curves were used to evaluate the diagnostic efficacy of ascitic soluble human leukocyte antigen-G for the detection of malignant ascites. Ascitic soluble human leukocyte antigen-G levels were significantly higher in the malignant ascites group than in the benign ascites group (20.718 ± 3.215 versus 12.467 ± 3.678 µg/L, t = 7.425, p