Psychological intervention based on psychoneuroimmunology improves clinical evolution, quality of life, and immunity of children with leukemia: A preliminary study

We conducted a non-randomized, open-label clinical trial to assess whether a psychoneuroimmunology-based intervention enhanced immunity in children with acute lymphoblastic leukemia undergoing chemotherapy. In total, 16 children (44% female) received psychoneuroimmunology-based intervention, whereas...

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Bibliographic Details
Published in:Health psychology open 2019-01, Vol.6 (1), p.2055102919838902-2055102919838902
Main Authors: Chacin-Fernández, Josymar, Chacin Fuenmayor, Margarita, Piñerua-Shuhaibar, Lorena, Suarez-Roca, Heberto
Format: Article
Language:English
Subjects:
Analgesics
Antibiotics
Chemotherapy
Children
Clinical research
Clinical trials
Hematology
Hospital costs
Immunity
Immunoglobulins
Intervention Study
Leukemia
Psychoeducational treatment
Psychological intervention
Psychoneuroimmunology
Quality of life
Serum
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Summary:We conducted a non-randomized, open-label clinical trial to assess whether a psychoneuroimmunology-based intervention enhanced immunity in children with acute lymphoblastic leukemia undergoing chemotherapy. In total, 16 children (44% female) received psychoneuroimmunology-based intervention, whereas 12 (50% female) received health psychoeducation (controls). The primary outcome was immunity markers, being clinical conditions the secondary outcome. Psychoneuroimmunology-based intervention increased immune markers (CD8+ T, B, and natural killer cells, serum immunoglobulin A, and immunoglobulin M) and quality of life, whereas it shortens the duration of fever and use of antipyretics, antibiotics, analgesics, and respiratory therapy. Immunity markers correlated with clinical conditions. Thus, psychoneuroimmunology-based intervention could reduce hospital cost and increase patient well-being.
ISSN:2055-1029
2055-1029
DOI:10.1177/2055102919838902