Vitamin D and Ocular Diseases: A Systematic Review

The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-04, Vol.23 (8), p.4226
Main Authors: Chan, Hei-Nga, Zhang, Xiu-Juan, Ling, Xiang-Tian, Bui, Christine Huyen-Trang, Wang, Yu-Meng, Ip, Patrick, Chu, Wai-Kit, Chen, Li-Jia, Tham, Clement C, Yam, Jason C, Pang, Chi-Pui
Format: Article
Language:English
Subjects:
age-related macular degeneration
Calciferol
Cancer
Cell growth
Diabetes
Diabetes mellitus
Diabetic retinopathy
Diabetic Retinopathy - complications
Disease
Endothelium
Enzymes
Epidemiology
Eye
Eye diseases
Gene expression
Glaucoma
Glaucoma - complications
Glaucoma - etiology
Humans
Macular degeneration
Macular Degeneration - complications
Macular Degeneration - etiology
Metabolism
Metabolites
Myopia
ocular disease
Proteins
Retina
Retinoblastoma
Retinopathy
Review
Skin
Systematic review
Thyroid
Tumors
Uveitis
Vitamin D
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
vitamin D receptor
Vitamin deficiency
Vitamins
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Summary:The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), dry eye syndrome (DES), thyroid eye disease (TED), uveitis, retinoblastoma (RB), cataract, and others, from epidemiological, clinical and basic studies, and briefly discuss vitamin D metabolism in the eye. We searched two research databases for articles examining the association between vitamin D deficiency and different ocular diseases. One hundred and sixty-two studies were found. There is evidence on the association between vitamin D and myopia, AMD, DR, and DES. Overall, 17 out of 27 studies reported an association between vitamin D and AMD, while 48 out of 54 studies reported that vitamin D was associated with DR, and 25 out of 27 studies reported an association between vitamin D and DES. However, the available evidence for the association with other ocular diseases, such as glaucoma, TED, and RB, remains limited.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23084226