3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester

An efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is ea...

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Bibliographic Details
Published in:MolBank 2016-12, Vol.2016 (4), p.M919
Main Authors: Meng, Ge, Wang, Mei, Cheng, Ya-Nan, Chen, Kai, Tong, Jing, Zhang, Jie-He
Format: Article
Language:English
Subjects:
2,3-dihydro-1,3-thiazole
Chemical synthesis
Methods
N,N′-diethylthiourea
one-pot synthesis
R&D
Research & development
Sulfur
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Summary:An efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is easy and gives the pure target compound under milder reaction conditions in a relatively high yield of 75%.
ISSN:1422-8599
1422-8599
DOI:10.3390/M919