A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression

Gamma-butyrobetaine hydroxylase 1 antisense RNA 1 (BBOX1-AS1), located on human chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic effects. Aberrant expression of BBOX1-AS1 intricately regulates various cellular processes, including cell growth, epithelial–mesenc...

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Bibliographic Details
Published in:Cancer cell international 2023-11, Vol.23 (1), p.1-263, Article 263
Main Authors: Hu, Juan, Liu, Jipeng, Zhou, Siwei, Luo, Hongliang
Format: Article
Language:English
Subjects:
Antisense RNA
Antisense therapy
Apoptosis
Autophagy
BBOX1-AS1
Carcinogenesis
Cell cycle
Cell death
Cell growth
Cell migration
CeRNA network
Cervical cancer
Chromosome 11
Cytoplasm
Drug resistance
Esophageal cancer
Ferroptosis
Gastric cancer
Gene expression
Hepatocellular carcinoma
Liver cancer
Lung cancer
Lymphatic system
Medical prognosis
Metastases
Metastasis
MicroRNAs
Molecular modelling
mRNA
Ovarian cancer
Predictive biomarker
Review
Signaling pathway
Tumorigenesis
Tumors
Wnt protein
β-Catenin
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Summary:Gamma-butyrobetaine hydroxylase 1 antisense RNA 1 (BBOX1-AS1), located on human chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic effects. Aberrant expression of BBOX1-AS1 intricately regulates various cellular processes, including cell growth, epithelial–mesenchymal transition, migration, invasion, metastasis, cell death, and stemness. Notably, the expression of BBOX1-AS1 was significantly correlated with clinical-pathological characteristics and tumor prognoses, and it could also be used for the diagnosis of lung and esophageal cancers. Through its involvement in the ceRNA network, BBOX1-AS1 competitively binds to eight miRNAs in ten different cancer types. Additionally, BBOX1-AS1 can directly modulate downstream protein-coding genes or act as an mRNA stabilizer. The implications of BBOX1-AS1 extend to critical signaling pathways, including Hedgehog, Wnt/β-catenin, and MELK/FAK pathways. Moreover, it influences drug resistance in hepatocellular carcinoma. The present study provides a systematic review of the clinical significance of BBOX1-AS1’s aberrant expression in diverse tumor types. It sheds light on the intricate molecular mechanisms through which BBOX1-AS1 influences cancer initiation and progression and outlines potential avenues for future research in this field.
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-023-03113-3