Cell Transdifferentiation and Reprogramming in Disease Modeling: Insights into the Neuronal and Cardiac Disease Models and Current Translational Strategies

Cell transdifferentiation and reprogramming approaches in recent times have enabled the manipulation of cell fate by enrolling exogenous/artificial controls. The chemical/small molecule and regulatory components of transcription machinery serve as potential tools to execute cell transdifferentiation...

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Published in:Cells (Basel, Switzerland) Switzerland), 2021-09, Vol.10 (10), p.2558
Main Authors: Kalra, Rajkumar Singh, Dhanjal, Jaspreet Kaur, Das, Mriganko, Singh, Birbal, Naithani, Rajesh
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Brain research
cardiac disease
Cardiomyocytes
Cell fate
cell reprogramming
Cell Transdifferentiation
Cellular Reprogramming - genetics
Coronary artery disease
disease modeling
Disease Models, Animal
Drug discovery
Fibroblasts
Gene therapy
Genotype & phenotype
Heart diseases
Heart Diseases - genetics
Humans
induced pluripotency
Mice
neuronal diseases
Neurons
Regenerative medicine
Review
Spinal cord injuries
Stem cells
Transcription
Transcription factors
transdifferentiation
Translation
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Summary:Cell transdifferentiation and reprogramming approaches in recent times have enabled the manipulation of cell fate by enrolling exogenous/artificial controls. The chemical/small molecule and regulatory components of transcription machinery serve as potential tools to execute cell transdifferentiation and have thereby uncovered new avenues for disease modeling and drug discovery. At the advanced stage, one can believe these methods can pave the way to develop efficient and sensitive gene therapy and regenerative medicine approaches. As we are beginning to learn about the utility of cell transdifferentiation and reprogramming, speculations about its applications in translational therapeutics are being largely anticipated. Although clinicians and researchers are endeavoring to scale these processes, we lack a comprehensive understanding of their mechanism(s), and the promises these offer for targeted and personalized therapeutics are scarce. In the present report, we endeavored to provide a detailed review of the original concept, methods and modalities enrolled in the field of cellular transdifferentiation and reprogramming. A special focus is given to the neuronal and cardiac systems/diseases towards scaling their utility in disease modeling and drug discovery.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10102558