Rapid Campimetry in glaucoma – correspondence with standard perimetry and OCT

• Published in: Scientific reports 2024-10, Vol.14 (1), p.25400-14, Article 25400
• Main Authors: Djouoma, Nidele, Müller, Fabian, Stolle, Francie H., Hoffmann, Friedrich, Thieme, Hagen, Hoffmann, Michael B., Al-Nosairy, Khaldoon O.
• Format: Article
• Language: English
• Subjects: 631/378; 631/378/2613; 631/378/2613/1483; 631/378/2613/1786; Acuity; Aged; Agreements; Automation; Case-Control Studies; Eye; Female; Glaucoma; Glaucoma - diagnosis; Glaucoma - diagnostic imaging; Humanities and Social Sciences; Humans; Kinetic VF; Male; Middle Aged; multidisciplinary; OCT; Quality of life; Rapid Campimetry; Retina; Retinal Ganglion Cells - pathology; Science; Science (multidisciplinary); Structure-function correlation; Structure-function relationships; Tomography, Optical Coherence - methods; Visual field; Visual Field Tests - methods; Visual Fields
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-75037-5

The Rapid Campimetry (RC), a kinetic visual field test proved to reliably detect visual field defects within the central 10° degrees, the most crucial part for visual acuity and quality of life, affected even at very early stages of glaucoma, within a short measurement epoch, ~ 1 min. This study aims to further investigate RC correspondence with standard tests in glaucoma, namely standard automated perimetry (SAP) and optical coherence tomography (OCT) within 10° of visual field (VF). For this purpose, we included 41 participants, [21 glaucoma (GLA, mean age: 65.9 ± 12.4; 12 preperimetric eyes and 11 with VF defects) and 20 healthy controls (HC; mean age: 65.0 ± 10.3); 20 eyes]. At first, we compared the rate of detection/exclusion of VF defects in RC vs. SAP. Then, for those with VF defects (11 eyes), we investigated the 68-pointwise correspondence of 10 − 2 layout of RC and SAP. For functional and structural (SF) correspondence, pointwise correspondence of RC, SAP vs. OCT macula [ macular ganglion cell thickness (GCL)] was also performed. Further, we compared sector-based correspondence of RC, SAP vs. OCT macula accounting for GCL displacement at the fovea as well as sector-based correspondence with OCT disc [peripapillary retinal nerve fiber layer thickness (pRNFL)]. Agreement estimates were reported along with Cohen Kappa ( ) statistic. For overall performance, RC and SAP showed 100% agreement ( ) for the exclusion of VF defects (HC and preperimetric GLA) and for detection of VF defects [11 eyes of 9 GLA, ( ]. Further, RC outperformed SAP in detection of arcuate scotomas, 7 vs. 5, respectively. Pointwise correspondence of VF defects (11 eyes), RC-SAP agreement reached 90% accuracy ( ). For SF correspondence, RC [SAP] showed 62% [69%] pointwise agreement with OCT macula , ( ). For macular sector-based correspondence, SF correspondence improved and reached 83% [83%] agreement, ( ). For OCT disc sector-based analysis, SF correspondence was highest, 100% [100%] agreement, ( ). Rapid Campimetry gave reproducible results in comparison to SAP and OCT with high potential as a screening VF method given its short testing duration, ~ 1 min in screening mode, and compatibility with telemedicine technologies upon future optimization and automation.