Study of the significance of the combination of the fibrinogen-albumin ratio and sarcopenia in predicting the prognosis of laryngeal cancer patients undergoing radical surgery

This study aims to investigate how the impact of preoperative sarcopenia and inflammatory markers for laryngeal cancer patients and develop a new scoring system to predict their prognosis. Patients who underwent laryngectomy for laryngeal cancer (LC) from December 2015 to December 2020 at the Second...

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Bibliographic Details
Published in:BMC cancer 2024-10, Vol.24 (1), p.1265-13, Article 1265
Main Authors: Zhang, Yizheng, Meng, Zhiyong, Lu, Ming, Ruan, Shenjiong, Zhou, Jiao, Zhang, Mingchen, Huang, Yanjun, Chen, Kehui, Luo, Xinyuan, Xie, Cheng-Ke, Zheng, Chaohui
Format: Article
Language:English
Subjects:
Aged
Albumin
Body mass index
Care and treatment
Complications and side effects
FAR
Female
Fibrinogen
Fibrinogen - analysis
Fibrinogen - metabolism
Health aspects
Humans
Inflammation
Laryngeal cancer
Laryngeal Neoplasms - blood
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
Laryngectomy - adverse effects
Lymphatic system
Male
Measurement
Medical prognosis
Metastasis
Middle Aged
Multivariate analysis
Neoplasm Staging
Nomograms
Patients
Preoperative sarcopenia
Prognosis
Proteins
Regression analysis
Retrospective Studies
Sarcopenia
Sarcopenia - blood
Sarcopenia - etiology
Serum Albumin - analysis
Serum Albumin - metabolism
Software
Surgery
Surgical outcomes
Survival analysis
Tumors
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Description
Summary:This study aims to investigate how the impact of preoperative sarcopenia and inflammatory markers for laryngeal cancer patients and develop a new scoring system to predict their prognosis. Patients who underwent laryngectomy for laryngeal cancer (LC) from December 2015 to December 2020 at the Second Affiliated Hospital of Fujian Medical University were included. Independent prognostic factors were determined using univariate and multivariate analyses. A new scoring system (SFAR) was established based on FAR and preoperative sarcopenia, and statistically analyzed. 198 cases included in this study that met the admission criteria. Multivariate analysis shown that preoperative sarcopenia, pTNM stage, and FAR were independent prognostic factors for laryngeal cancer. Based on these three indicators, we developed the SFAR scoring system. Multivariate analysis showed that SFAR was an independent predictor of laryngeal cancer (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-024-13039-2