Nucleosome Remodeling by Fun30SMARCAD1 in the DNA Damage Response

Many cellular pathways are dedicated to maintain the integrity of the genome. In eukaryotes, the underlying DNA transactions occur in the context of chromatin. Cells utilize chromatin and its dynamic nature to regulate those genome integrity pathways. Accordingly, chromatin becomes restructured and...

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Bibliographic Details
Published in:Frontiers in molecular biosciences 2019-09, Vol.6, p.78-78
Main Authors: Bantele, Susanne C. S., Pfander, Boris
Format: Article
Language:English
Subjects:
cell cycle
DNA double-stranded break
DNA end resection
Fun30/SMARCAD1
Molecular Biosciences
nucleosome remodeling
post-translational modification
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Summary:Many cellular pathways are dedicated to maintain the integrity of the genome. In eukaryotes, the underlying DNA transactions occur in the context of chromatin. Cells utilize chromatin and its dynamic nature to regulate those genome integrity pathways. Accordingly, chromatin becomes restructured and modified around DNA damage sites. Here, we review the current knowledge of a chromatin remodeler Fun30 SMARCAD1 , which plays a key role in genome maintenance. Fun30 SMARCAD1 promotes DNA end resection and the repair of DNA double-stranded breaks (DSBs). Notably, however, Fun30 SMARCAD1 plays additional roles in maintaining heterochromatin and promoting transcription. Overall, Fun30 SMARCAD1 is involved in distinct processes and the specific roles of Fun30 SMARCAD1 at DSBs, replication forks and sites of transcription appear discordant at first view. Nonetheless, a picture emerges in which commonalities within these context-dependent roles of Fun30 SMARCAD1 exist, which may help to gain a more global understanding of chromatin alterations induced by Fun30 SMARCAD1 .
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2019.00078