Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock

Selective breeding of sheep for arginine (R) at prion gene (PRNP) codon 171 confers resistance to classical scrapie. However, other effects of 171R selection are uncertain. Ovine progressive pneumonia/Maedi-Visna virus (OPPV) may infect up to 66% of a flock thus any affect of 171R selection on OPPV...

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Bibliographic Details
Published in:Genetics selection evolution (Paris) 2009-01, Vol.41 (1), p.17-17, Article 17
Main Authors: Harrington, Robert D, Herrmann-Hoesing, Lynn M, White, Stephen N, O'Rourke, Katherine I, Knowles, Donald P
Format: Article
Language:English
Subjects:
Alleles
Animal husbandry
Animals
Arthritis
Confidence intervals
Disease
Encephalitis
Genes
Genetic aspects
Genetic polymorphisms
Genotype
Genotype & phenotype
Genotypes
Health aspects
Idaho
Maedi
Ovis aries
Pneumonia
Pneumonia, Progressive Interstitial, of Sheep - genetics
Pneumonia, Progressive Interstitial, of Sheep - virology
Prion diseases
Prions
Prions - genetics
Proviruses - physiology
Risk factors
Scrapie
Scrapie - genetics
Scrapie - virology
Selective breeding
Sheep
Sheep - genetics
Sheep - virology
Viruses
Visna
Visna-maedi virus - physiology
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Summary:Selective breeding of sheep for arginine (R) at prion gene (PRNP) codon 171 confers resistance to classical scrapie. However, other effects of 171R selection are uncertain. Ovine progressive pneumonia/Maedi-Visna virus (OPPV) may infect up to 66% of a flock thus any affect of 171R selection on OPPV susceptibility or disease progression could have major impact on the sheep industry. Hypotheses that the PRNP 171R allele is 1) associated with the presence of OPPV provirus and 2) associated with higher provirus levels were tested in an Idaho ewe flock. OPPV provirus was found in 226 of 358 ewes by quantitative PCR. The frequency of ewes with detectable provirus did not differ significantly among the 171QQ, 171QR, and 171RR genotypes (p > 0.05). Also, OPPV provirus levels in infected ewes were not significantly different among codon 171 genotypes (p > 0.05). These results show that, in the flock examined, the presence of OPPV provirus and provirus levels are not related to the PRNP 171R allele. Therefore, a genetic approach to scrapie control is not expected to increase or decrease the number of OPPV infected sheep or the progression of disease. This study provides further support to the adoption of PRNP 171R selection as a scrapie control measure.
ISSN:1297-9686
0999-193X
1297-9686
DOI:10.1186/1297-9686-41-17