Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review

Imbalances of the oral microbiota and dysbiosis have traditionally been linked to the occurrence of teeth and oral diseases. However, recent findings indicate that this microbiota exerts relevant influence in systemic health. Dysbiosis of the oral microbiota is implicated in the apparition and progr...

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Published in:Biomedicines 2022-07, Vol.10 (8), p.1803
Main Authors: Giordano-Kelhoffer, Barbara, Lorca, Cristina, March Llanes, Jaume, Rábano, Alberto, del Ser, Teodoro, Serra, Aida, Gallart-Palau, Xavier
Format: Article
Language:English
Subjects:
Bacteria
Brain research
cardiovascular disease
caries
Communication
Dental caries
Diet
Dysbacteriosis
dysbiosis
Enamel
Equilibrium
Gram-negative bacteria
gut microbiota
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Neurodegenerative diseases
Nutrition research
Oral diseases
oral microbiota
Pathology
periodontal disease
Physiological aspects
Reviews
Systematic Review
Systemic diseases
Teeth
Tumor necrosis factor-TNF
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Summary:Imbalances of the oral microbiota and dysbiosis have traditionally been linked to the occurrence of teeth and oral diseases. However, recent findings indicate that this microbiota exerts relevant influence in systemic health. Dysbiosis of the oral microbiota is implicated in the apparition and progression of cardiovascular, neurodegenerative and other major human diseases. In fact, the oral microbiota are the second most diverse and largely populated microbiota of the human body and its relationships with systemic health, although widely explored, they still lack of proper integration. The purpose of this systematic review is thus to widely examine the implications of oral microbiota in oral, cardiovascular and neurodegenerative diseases to offer integrative and up-to-date interpretations. To achieve that aim, we identified a total of 121 studies curated in PUBMED from the time interval January 2003–April 2022, which after careful screening resulted in 79 studies included. The reviewed scientific literature provides plausible vias of implication of dysbiotic oral microbiota in systemic human diseases, and encourages further research to continue elucidating the highly relevant and still poorly understood implications of this niche microbiota in systemic health. PROSPERO Registration Number: CRD42022299692. This systematic review follows relevant PRISMA guidelines.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10081803