Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities

By investigating of the roots of , which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides ( ⁻ ) that were previously undescribed, along with eight known ones ( ⁻ ). Their structure characteristics were assessed by HR-ES...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-12, Vol.23 (12), p.3274
Main Authors: Jin, Qinghao, Hu, Xinyi, Deng, Yanping, Hou, Jinjun, Lei, Min, Ji, Hongjian, Zhou, Jing, Qu, Hua, Wu, Wanying, Guo, Dean
Format: Article
Language:English
Subjects:
Acids
Alzheimer's disease
Apoptosis
Carbon
Chromatography
depsides
Experiments
HS-SY5Y
Hydrocarbons
Hydrogen peroxide
nerve-protection
Neuroblastoma
NMR
Nuclear magnetic resonance
Salvia miltiorrhiza
Solvents
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Summary:By investigating of the roots of , which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides ( ⁻ ) that were previously undescribed, along with eight known ones ( ⁻ ). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (¹H, C, HSQC, HMBC) data analyses. These four newly isolated compounds ( ⁻ ), as well as the other eight compounds ( ⁻ ), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells. Among them, depside and depside displayed more obviously protective effects than others.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23123274