Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells

The deleterious effects of aflatoxins, especially aflatoxin B1 (AFB1) which are widespread at all stages of food production, on the reproductive system have been widely reported in males. However, it is still far from fully understood about the toxic effect and molecular mechanism after exposure to...

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Published in:Ecotoxicology and environmental safety 2023-07, Vol.259, p.115063-115063, Article 115063
Main Authors: Han, Shuaiqi, Zhang, Hongyun, Liu, Xinyu, Wen, Fei, Li, Baiyu, Bie, Zhiwen, Qiu, Hehan, Hu, Jianhong
Format: Article
Language:English
Subjects:
AFB1
Aflatoxin B1 - toxicity
AMP-Activated Protein Kinases - metabolism
AMPK
Animals
Autophagy
Goats - metabolism
Lactate
Lactic Acid - metabolism
Male
Sertoli cells
Sertoli Cells - metabolism
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Summary:The deleterious effects of aflatoxins, especially aflatoxin B1 (AFB1) which are widespread at all stages of food production, on the reproductive system have been widely reported in males. However, it is still far from fully understood about the toxic effect and molecular mechanism after exposure to AFB1 in various testicular cells, especially Sertoli cells (SCs) which provide various energy materials and support to the developing germ cells as nurse cells. In this work, we examined the effects of AFB1 in dairy goat SCs on lactate production and autophagy, and the role of autophagy on AFB1-induced reduction in lactate production. Mechanistically, AFB1 destroyed the energy balance and reduced the secretion of lactate in dairy goat SCs (P 
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2023.115063