Pedunculopontine Gamma Band Activity and Development

This review highlights the most important discovery in the reticular activating system in the last 10 years, the manifestation of gamma band activity in cells of the reticular activating system (RAS), especially in the pedunculopontine nucleus, which is in charge of waking and rapid eye movement (RE...

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Bibliographic Details
Published in:Brain Sciences 2015-12, Vol.5 (4), p.546-567
Main Authors: Garcia-Rill, Edgar, Luster, Brennon, Mahaffey, Susan, MacNicol, Melanie, Hyde, James R, D'Onofrio, Stasia M, Phillips, Cristy
Format: Article
Language:English
Subjects:
basic rest-activity cycle
Brain research
Ca2+ channels
connexin 36
electrical coupling
Eye movements
parafascicular
preconscious awareness
REM sleep
reticular activating system
Review
Sleep
subcoeruleus
waking
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Summary:This review highlights the most important discovery in the reticular activating system in the last 10 years, the manifestation of gamma band activity in cells of the reticular activating system (RAS), especially in the pedunculopontine nucleus, which is in charge of waking and rapid eye movement (REM) sleep. The identification of different cell groups manifesting P/Q-type Ca(2+) channels that control waking vs. those that manifest N-type channels that control REM sleep provides novel avenues for the differential control of waking vs. REM sleep. Recent discoveries on the development of this system can help explain the developmental decrease in REM sleep and the basic rest-activity cycle.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci5040546